Overexpression of MiR‐335‐5p Promotes Bone Formation and Regeneration in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3230
Abstract: MicroRNAs (miRNAs) and the Wnt signaling pathway play critical roles in regulating bone development and homeostasis. Our previous study revealed high expression of miR‐335‐5p in osteoblasts and hypertrophic chondrocytes in mouse embryos and the ability… read more here.
Keywords: bone; mir 335; transgenic mice; bone formation ... See more keywords
Upregulated expression of ROCK1 promotes cell proliferation by functioning as a target of miR-335-5p in non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of cellular physiology"
DOI: 10.1002/jcp.28886
Abstract: Lung cancer is regarded as one of the dominant causes in cancer patients among men and women all over the world. Rho-associated coiled-coil forming protein kinase l (ROCK1) is characterized as pivotal downstream effectors of… read more here.
Keywords: cell proliferation; rock1; cancer; mir 335 ... See more keywords
Downregulation of circ‐ZNF644 alleviates LPS‐induced HK2 cell injury via miR‐335‐5p/HIPK1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23642
Abstract: Circular RNA (circRNA) has been confirmed to be involved in regulating sepsis‐induced acute kidney injury (AKI). Our research aims to explore circ‐ZNF644 role in the development of sepsis‐induced AKI. Lipopolysaccharide (LPS) was used to induce… read more here.
Keywords: cell; mir 335; znf644; injury ... See more keywords
The clinical significance of miR-335, miR-124, miR-218 and miR-484 downregulation in gastric cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology Reports"
DOI: 10.1007/s11033-018-4278-5
Abstract: Gastric cancer (GC) is one of the leading types of malignancy worldwide, particularly in Asian populations. Although the exact molecular mechanism of GC development remains unknown, microRNA (miRNA) has recently been shown to be involved.… read more here.
Keywords: mir 218; mir; 124 mir; downregulation ... See more keywords
Circ_0011058 facilitates proliferation, angiogenesis and radioresistance in papillary thyroid cancer cells by positively regulating YAP1 via acting as miR-335-5p sponge.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.110155
Abstract: BACKGROUND Circular RNAs (circRNAs) are reported to be associated with multiple biological processes in human cancers. However, there are still numerous circRNAs whose functions remain unclear. The aim of this study was to investigate the… read more here.
Keywords: circ 0011058; mir 335; radioresistance; proliferation angiogenesis ... See more keywords
Upregulation of microRNA‐335‐5p reduces inflammatory responses by inhibiting FASN through the activation of AMPK/ULK1 signaling pathway in a septic mouse model
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.05.016
Abstract: &NA; Sepsis, as a systemic inflammatory response syndrome (SIRS) subtype, is generally characterized by infection. Emerging evidence has highlighted dysregulated microRNAs (miRNAs) are involved in the progression of sepsis. The aim of the study was… read more here.
Keywords: ampk ulk1; septic mouse; signaling pathway; ulk1 signaling ... See more keywords
MiR-335 regulates the chemo-radioresistance of small cell lung cancer cells by targeting PARP-1.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2016.11.031
Abstract: The role of miR-335 in the regulation of chemosensitivity and radiosensitivity of small cell lung cancer (SCLC) was investigated. miR-335 was significantly downregulated in multi-drug-resistant SCLC H69AR and H446DDP cells compared with parental cells as… read more here.
Keywords: lung cancer; cell lung; parp; mir 335 ... See more keywords
Overexpression of miR-335 inhibits the migration and invasion of osteosarcoma by targeting SNIP1.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.04.016
Abstract: MicroRNAs (miRNAs) are key regulators in the development and progression of osteosarcoma (OS). Based on our previous microarray data, we found that miR-335 expression was downregulated in OS tissue relative to normal tissue. Herein, we… read more here.
Keywords: overexpression mir; snip1; invasion; migration ... See more keywords
The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.08.003
Abstract: MiR-335-3p, a neuron-enriched microRNA, has been reported to be involved in aging and age-related neurological diseases. However, the role of miR-335-3p in cholesterol metabolism of astrocytes, and whether it affects neuronal functions, particularly during aging… read more here.
Keywords: age; cholesterol metabolism; cholesterol; mir 335 ... See more keywords
Downregulation of miR-335 exhibited an oncogenic effect via promoting KDM3A/YAP1 networks in clear cell renal cell carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer gene therapy"
DOI: 10.1038/s41417-021-00335-3
Abstract: Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cancer affecting many people worldwide. Although the 5-year survival rate is 65% in localized disease, after metastasis, the survival rate is read more here.
Keywords: ccrcc; kdm3a yap1; mir 335; cell ... See more keywords
Extracellular vesicles produced in B cells deliver tumor suppressor miR-335 to breast cancer cells disrupting oncogenic programming in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35968-2
Abstract: The successful implementation of miRNA (miR) therapies in humans will ultimately rely on the use of vehicles with improved cellular delivery capability. Here we tested a new system that leverages extracellular vesicles (EVs) laden with… read more here.
Keywords: tumor suppressor; mir 335; cancer cells;