α‐Pinene inhibits the growth of cervical cancer cells through its proapoptotic activity by regulating the miR‐34a‐5p/Bcl‐2 signaling axis
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DOI: 10.1002/ddr.21994
Abstract: Among gynecological tumors, cervical cancer (CC) has the second‐highest prevalence and mortality rate. α‐Pinene is a bicyclic monoterpenoid compound extracted from pine needles that carried promising anticancer properties. Nevertheless, its effect on CC and the… read more here.
Keywords: pinene; cervical cancer; apoptosis; hela cells ... See more keywords
miR‐34a Targets HDAC1‐Regulated H3K9 Acetylation on Lipid Accumulation Induced by Homocysteine in Foam Cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26126
Abstract: Hyperhomocysteinemia (HHcy) promotes atherogenesis by modification of histone acetylation patterns and regulation of miRNA expression while the underlying molecular mechanisms are not well known. In this study, we investigated the effects of homocysteine (Hcy) on… read more here.
Keywords: accumulation; acetylation; mir 34a; expression ... See more keywords
Knockdown of long non‐coding RNA ANRIL inhibits proliferation, migration, and invasion but promotes apoptosis of human glioma cells by upregulation of miR‐34a
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26437
Abstract: Gliomas are the most common types of primary central nervous system malignancy found in adults. Long non‐coding RNA antisense non‐coding RNA in the INK4 locus (ANRIL) variants are associated with glioma and miR‐34a is markedly… read more here.
Keywords: sirt1; glioma; mir 34a; proliferation ... See more keywords
Identification of hsa‐mir‐34a, hsa‐mir‐124, and hsa‐mir‐204 as signatures for cataract
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27741
Abstract: Cataract, one of the common age‐related diseases that remains the leading cause of blindness worldwide. There have been studies pertaining to microRNA (miRNA) effects on cataract pathogenesis. However, the results were different from each other… read more here.
Keywords: target genes; hsa mir; mir 34a; hsa ... See more keywords
KCNQ1OT1 sponges miR‐34a to promote malignant progression of malignant melanoma via upregulation of the STAT3/PD‐L1 axis
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DOI: 10.1002/tox.23687
Abstract: Malignant melanoma is a leading cause of skin cancer‐related death. In over 30% of cases, the melanoma is invasive and has a metastatic phenotype. KCNQ1 overlapping transcript 1 (KCNQ1OT1) was previously identified as an oncogenic… read more here.
Keywords: malignant melanoma; melanoma; kcnq1ot1 sponges; 34a promote ... See more keywords
miRNA-34a inhibits cell adhesion by targeting CD44 in human renal epithelial cells: implications for renal stone disease
Sign Up to like & getrecommendations! Published in 2019 at "Urolithiasis"
DOI: 10.1007/s00240-019-01155-9
Abstract: Nephrolithiasis is a very common disease in which cell–crystal adhesion is an essential mechanism for kidney stone formation. This study has explored the anti-adhesion function of the microRNA, miR-34a, by targeting CD44, a cell surface… read more here.
Keywords: stone; mir 34a; adhesion; disease ... See more keywords
Bioengineering of a single long noncoding RNA molecule that carries multiple small RNAs
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-09934-5
Abstract: Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), small interfering RNAs (siRNAs), and long noncoding RNAs (lncRNAs), regulate target gene expression and can be used as tools for understanding biological processes and identifying new therapeutic targets. Currently,… read more here.
Keywords: long noncoding; pre mir; mir 34a; multiple small ... See more keywords
Downregulation of miR-34a promotes endothelial cell growth and suppresses apoptosis in atherosclerosis by regulating Bcl-2
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DOI: 10.1007/s00380-018-1169-6
Abstract: Several miRNAs have been demonstrated to be involved in endothelial dysfunction during atherosclerosis (AS). However, the detailed roles and underlying mechanisms of miR-34a in AS-associated endothelial cell apoptosis are far from being addressed. Apolipoprotein E-deficient… read more here.
Keywords: apoptosis; mir 34a; endothelial cell; cell growth ... See more keywords
Senescence-associated miR-34a and miR-126 in middle-aged Indians with type 2 diabetes
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DOI: 10.1007/s10238-019-00593-4
Abstract: Rapid urbanization and unhealthy dietary patterns critically increase the risk of type 2 diabetes (T2D) in middle-aged Indians. However, despite recent evidence of senescence-associated microRNAs (SA-miRNAs) in regulating complex pathways of ageing, their expressions in middle-aged… read more here.
Keywords: mir 126; senescence associated; mir 34a; middle aged ... See more keywords
MicroRNA-34a Suppresses Autophagy in Alveolar Type II Epithelial Cells in Acute Lung Injury by Inhibiting FoxO3 Expression
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DOI: 10.1007/s10753-017-0537-1
Abstract: Excessive autophagic activity of alveolar type II epithelial (AT-II) cells is one of the main causes of acute lung injury (ALI); however, the underlying molecular mechanism remains to be determined. The microRNAs (miRNAs) are involved… read more here.
Keywords: alveolar type; mir 34a; expression; autophagic activity ... See more keywords
IL-6 induces tumor suppressor protein tyrosine phosphatase receptor type D by inhibiting miR-34a to prevent IL-6 signaling overactivation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03803-w
Abstract: Protein tyrosine phosphatase receptor type D (PTPRD) is a tumor suppressor gene that is epigenetically silenced and mutated in several cancers, including breast cancer. Since IL-6/STAT3 signaling is often hyperactivated in breast cancer and STAT3… read more here.
Keywords: tumor suppressor; ptprd; mir 34a; breast cancer ... See more keywords