Downregulation of miR‐34c‐5p alleviates chronic intermittent hypoxia‐induced myocardial damage by targeting sirtuin 1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23164
Abstract: Numerous microRNAs (miRs) are abnormally expressed in response to hypoxia‐induced myocardial damage. Herein, miR‐34c‐5p as a potential pharmaco‐target was investigated in a mouse model of chronic intermittent hypoxia (CIH)‐induced myocardial damage. A mouse model of… read more here.
Keywords: mir 34c; myocardial damage; antagomir 34c; hypoxia ... See more keywords
Osthole ameliorates simulated microgravity-induced bone loss through down-regulation of miR-34c-5p
Sign Up to like & getrecommendations! Published in 2021 at "Acta Astronautica"
DOI: 10.1016/j.actaastro.2021.03.015
Abstract: Abstract Bone loss severely threatens the heath of astronauts in long-term spaceflight and the effects of the developed countermeasures are limited. Emerging studies have revealed the positive role of osthole (OST) in induction of osteogenic… read more here.
Keywords: expression; bone loss; simulated microgravity; mir 34c ... See more keywords
MiR-34c and PlncRNA1 mediated the function of intestinal epithelial barrier by regulating tight junction proteins in inflammatory bowel disease.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.115
Abstract: BACKGROUND Inflammatory bowel disease (IBD) is originated from uncontrolled inflammation, and desired methods for IBD therapy remains the main difficult. The network comprised with miRNA and lncRNA has been verified to play an important role… read more here.
Keywords: intestinal epithelial; barrier; function intestinal; plncrna1 ... See more keywords
MicroRNA-34c promotes osteoclast differentiation through targeting LGR4.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2017.01.028
Abstract: MicroRNAs have emerged as important regulators of osteoclast differentiation in recent years. Of these, miR-34c has been reported to play an important role in bone development. However, its role and the underlying mechanism in osteoclast… read more here.
Keywords: targeting lgr4; osteoclast differentiation; microrna 34c; differentiation ... See more keywords
Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrin α2β1
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-0133-y
Abstract: Exosomes play critical roles in regulating various physiological and pathological processes, including immune stimulation, immune suppression, cardiovascular diseases, and cancers. Recent studies show that exosomes that transport specific microRNAs (miRNAs) are involved in tumor development.… read more here.
Keywords: nsclc cells; invasion migration; upregulating integrin; migration ... See more keywords
Knockdown of the oncogene lncRNA NEAT1 restores the availability of miR-34c and improves the sensitivity to cisplatin in osteosarcoma
Sign Up to like & getrecommendations! Published in 2018 at "Bioscience Reports"
DOI: 10.1042/bsr20180375
Abstract: Aberrant expressions of long non-coding RNAs (lncRNAs) are the culprits of carcinogenesis via regulating the tumor suppressor or oncogene. LncRNA nuclear enriched abundant transcript 1 (NEAT1) has been identified to be an oncogene to promote… read more here.
Keywords: tumor; oncogene lncrna; sensitivity cisplatin; mir 34c ... See more keywords
MiR-34c inhibits proliferation of glioma by targeting PTP1B.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmaa178
Abstract: Glioma is one of the most pervasive and invasive primary malignancies in the central nervous system. Due to its abnormal proliferation, glioma remains hard to cure at present. Protein tyrosine phosphatase 1B (PTP1B) has been… read more here.
Keywords: proliferation glioma; glioma; proliferation; inhibits proliferation ... See more keywords
miR-34c-5p functions as pronociceptive microRNA in cancer pain by targeting Cav2.3 containing calcium channels
Sign Up to like & getrecommendations! Published in 2017 at "Pain"
DOI: 10.1097/j.pain.0000000000000971
Abstract: Abstract Pathophysiological mechanisms underlying pain associated with cancer are poorly understood. microRNAs (miRNAs) are a class of noncoding RNAs with emerging functional importance in chronic pain. In a genome-wide screen for miRNAs regulated in dorsal… read more here.
Keywords: cancer pain; sensory neurons; cav2; pain ... See more keywords
Increased miR‐34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS‐JNK‐p53 pathway in Alzheimer’s Disease
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DOI: 10.1111/acel.13125
Abstract: Alzheimer's disease (AD) and cancer have inverse relationship in many aspects. Some tumor suppressors, including miR‐34c, are decreased in cancer but increased in AD. The upstream regulatory pathways and the downstream mechanisms of miR‐34c in… read more here.
Keywords: ros jnk; jnk p53; increased mir; p53 pathway ... See more keywords
Expression of miR‐18a and miR‐34c in circulating monocytes associated with vulnerability to type 2 diabetes mellitus and insulin resistance
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13240
Abstract: Chronic stress may facilitate the development of metabolic disorders including insulin resistance (IR) and type 2 diabetes mellitus (T2DM). MiR‐18a and miR‐34c modulate central cell responsiveness to stress by targeting glucocorticoid receptor (GR) and corticotropin‐releasing… read more here.
Keywords: 18a mir; expression; mir 18a; insulin resistance ... See more keywords
Hsa_circ_0003945 promotes progression of hepatocellular carcinoma by mediating miR‐34c‐5p/LGR4/β‐catenin axis activity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17243
Abstract: Accumulating evidence suggests that circular RNAs (circRNAs) play essential roles in regulating cancer progression, but many circRNAs in hepatocellular carcinoma (HCC) remain unknown. Dysregulated circRNAs in HCC were identified through bioinformatics analysis of Gene Expression… read more here.
Keywords: hepatocellular carcinoma; mir 34c; hcc; hsa circ ... See more keywords