Lnc2300 is a cis‐acting long noncoding RNA of CYP11A1 in ovarian granulosa cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30872
Abstract: The high level of progesterone and 17β‐estradiol ratio (P4/E2) in follicular fluid has been considered as a biomarker of follicular atresia. CYP11A1, the crucial gene encoding the rate‐limiting enzyme for steroid hormone synthesis, has been… read more here.
Keywords: follicular atresia; cyp11a1; rna; mir 365 ... See more keywords
Exosomes derived from imatinib‐resistant chronic myeloid leukemia cells mediate a horizontal transfer of drug‐resistant trait by delivering miR‐365
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.12.001
Abstract: &NA; Chronic myeloid leukemia (CML) is a malignant disorder of hematopoietic stem/progenitor cells. Majority of patients can be effectively treated with tyrosine kinase inhibitors (TKIs) such as imatinib, but a portion of patients will develop… read more here.
Keywords: cml; myeloid leukemia; exosomes derived; drug ... See more keywords
MicroRNA-365 regulates human cardiac action potential duration
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27856-7
Abstract: Abnormalities of ventricular action potential cause malignant cardiac arrhythmias and sudden cardiac death. Here, we aim to identify microRNAs that regulate the human cardiac action potential and ask whether their manipulation allows for therapeutic modulation… read more here.
Keywords: cardiac action; mir 365; action; human cardiac ... See more keywords
THU0050 Microrna-365 inhibits il-1β-induced catabolic factor expression by targeting hif-2α in human primary chondrocytes
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.2818
Abstract: Background MicroRNAs, small noncoding RNA molecules, are involved in the pathogenesis of various diseases such as cancer and arthritis. Endothelial PAS domain protein-1/hypoxia-inducible factor-2α (EPAS-1/ HIF-2α) is a catabolic transcription factor that regulates osteoarthritis (OA)… read more here.
Keywords: hif; microrna 365; expression; factor ... See more keywords
Transfer of miRNA in Macrophage-Derived Exosomes Induces Drug Resistance in Pancreatic Adenocarcinoma.
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DOI: 10.1158/0008-5472.can-18-0124
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is known for its resistance to gemcitabine, which acts to inhibit cell growth by termination of DNA replication. Tumor-associated macrophages (TAM) were recently shown to contribute to gemcitabine resistance; however, the… read more here.
Keywords: gemcitabine; resistance; transfer; macrophage derived ... See more keywords
FOXK1, Regulated by miR-365-3p, Promotes Cell Growth and EMT Indicates Unfavorable Prognosis in Breast Cancer
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s212702
Abstract: Background Forkhead box K1 (FOXK1) is members of the FOX transcription factor family. Previous work has found out that FOXK1 promotes cell proliferation, migration and invasion in several cancers, such as gastric cancer, glioma cancer… read more here.
Keywords: foxk1; mir 365; cancer; promotes cell ... See more keywords