The PGC-1α/NRF1/miR-378a axis protects vascular smooth muscle cells from FFA-induced proliferation, migration and inflammation in atherosclerosis.
Sign Up to like & getrecommendations! Published in 2020 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2020.02.001
Abstract: BACKGROUND AND AIMS Atherosclerosis (AS) is the leading cause of cardiovascular diseases. PGC-1α is a key regulator of cellular energy homeostasis, but its role in AS remains debatable. METHODS AND RESULTS In our study, PGC-1α… read more here.
Keywords: mir; vascular smooth; muscle cells; smooth muscle ... See more keywords
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-02851-7
Abstract: Previously we have reported that metastatic melanoma cell lines and tumor specimens have reduced expression of ADAR1 and consequently are impaired in their ability to perform A-to-I microRNA (miRNA) editing. The effects of A-to-I miRNAs… read more here.
Keywords: melanoma; melanoma progression; edited form; expression ... See more keywords
microRNA-378a-3p regulates the progression of hepatocellular carcinoma by regulating PD-L1 and STAT3
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2031408
Abstract: ABSTRACT Programmed death ligand 1 (PD-L1) plays an essential role in the development or progression of hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression during normal and pathophysiological events. Here,… read more here.
Keywords: regulating stat3; mir 378a; hepatocellular carcinoma; progression hepatocellular ... See more keywords
LncRNA MALAT1 promotes tenogenic differentiation of tendon-derived stem cells via regulating the miR-378a-3p/MAPK1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2076507
Abstract: ABSTRACT Tendinopathy is a type of chronic injury caused by repeated pulling. Previous studies have reported that long non-coding RNA MALAT1 (MALAT1) regulates a variety of genes affecting bone metabolism. This study aimed to explore… read more here.
Keywords: malat1; mapk1 axis; mir 378a; 378a mapk1 ... See more keywords
P0147 Regulation of Inflammatory Pathways by miR-338-3p and miR-378a-3p: A Novel Approach for Crohn’s Disease Treatment
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjae190.0321
Abstract: MicroRNAs (miRNAs), key regulators of gene expression, are promising biomarkers and therapeutic targets in inflammatory bowel disease (IBD) due to their roles in immune response and tissue integrity. This study explores miRNA roles in IBD,… read more here.
Keywords: mir 338; crohn disease; 338 mir; mir 378a ... See more keywords
miR‐125b‐1 and miR‐378a are predictive biomarkers for the efficacy of vaccine treatment against colorectal cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Science"
DOI: 10.1111/cas.13390
Abstract: Many clinical trials of peptide vaccines have been conducted. However, these vaccines have provided clinical benefits in only a small fraction of patients. The purpose of the present study was to explore microRNAs (miRNAs) as… read more here.
Keywords: vaccine treatment; mir; efficacy vaccine; cancer ... See more keywords
Brain Leptin Receptor Activation May Improve Cardiac Function After Ischemia-Reperfusion Injury by Stimulating Release of miR-378a-5p-enriched EVs from Brown Adipocytes
Sign Up to like & getrecommendations! Published in 2025 at "Physiology"
DOI: 10.1152/physiol.2025.40.s1.0598
Abstract: Ischemic heart disease is the leading cause of death worldwide. Our recent studies demonstrated that activating brain leptin receptors (LepRs) through intracerebroventricular (ICV) infusion of leptin improves cardiac function after ischemia/reperfusion (IR) injury. However, the… read more here.
Keywords: brain; physiology; treated rats; bat ... See more keywords
LINC01023 Promotes the Hepatoblastoma Tumorigenesis via miR-378a-5p/WNT3 Axis.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and cellular biochemistry"
DOI: 10.21203/rs.3.rs-1283178/v1
Abstract: Hepatoblastoma is the most common type of hepatic tumors occurring in children between 0 and 5 years. And the exact pathophysiology of the disease is still mysterious. Accumulating studies on LncRNA have shown its pivotal role… read more here.
Keywords: cell; mir 378a; hepatoblastoma; linc01023 ... See more keywords
CircCRIM1 Promotes Hepatocellular Carcinoma Proliferation and Angiogenesis by Sponging miR-378a-3p and Regulating SKP2 Expression
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.796686
Abstract: Mounting evidence has demonstrated that circular RNAs have an important function in tumorigenesis and cancer evolvement. CircCRIM1 has been shown to be a poor prognostic element in multiple human malignancies. However, the clinical significance and… read more here.
Keywords: circcrim1; proliferation angiogenesis; expression; hcc ... See more keywords
Corrigendum: MiR-378a-5p Regulates Proliferation and Migration in Vascular Smooth Muscle Cell by Targeting CDK1
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2019.00193
Abstract: [This corrects the article DOI: 10.3389/fgene.2019.00022.]. read more here.
Keywords: proliferation migration; regulates proliferation; 378a regulates; corrigendum mir ... See more keywords
Inhibition of miR-378a-3p by Inflammation Enhances IL-33 Levels: A Novel Mechanism of Alarmin Modulation in Ulcerative Colitis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02449
Abstract: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by mucosa damage associated with an uncontrolled inflammatory response. This immunological impairment leads to altered inflammatory mediators such as IL-33, which is shown to increase… read more here.
Keywords: mir 378a; expression; ulcerative colitis; mechanism ... See more keywords