Long noncoding RNA HOXD‐AS1 induces epithelial‐mesenchymal transition in breast cancer by acting as a competing endogenous RNA of miR‐421
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28353
Abstract: Breast cancer (BCa) is the most common malignant tumor in females. Long noncoding RNAs (lncRNAs) are deregulated in many types of human cancers, including BCa. The purpose of the present study was to examine the… read more here.
Keywords: bca; mir 421; hoxd as1; breast cancer ... See more keywords
MicroRNA‐421 suppresses the apoptosis and autophagy of hippocampal neurons in epilepsy mice model by inhibition of the TLR/MYD88 pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26498
Abstract: Epilepsy is a group of neurological disorders characterized by epileptic seizures. In this study, we aim to explore the role of microRNA‐421 (miR‐421) in hippocampal neurons of epilepsy mice via the TLR/MYD88 pathway. Forty mice… read more here.
Keywords: hippocampal neurons; tlr myd88; neurons epilepsy; model ... See more keywords
MiR-421 regulates goat intramuscular preadipocytes differentiation via targeting FGF13.
Sign Up to like & getrecommendations! Published in 2021 at "Animal biotechnology"
DOI: 10.1080/10495398.2021.1898414
Abstract: As a member of the MicroRNA s (miRNAs) family, miR-421 has been widely studied in regulating the proliferation and apoptosis of cancer cells a. However, there are still no reports on miR-421 in regulating adipocyte… read more here.
Keywords: goat intramuscular; expression; differentiation; mir 421 ... See more keywords
Mechanism of lncRNA SNHG16 in oxidative stress and inflammation in oxygen-glucose deprivation and reoxygenation-induced SK-N-SH cells
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2026861
Abstract: ABSTRACT Cerebral ischemia-reperfusion injury imposes a clinical challenge for physicians in the wake of ischemic stroke. Meanwhile, recent evidence has come to light eliciting the neuroprotective function of SNHG16 in cerebrovascular diseases. Accordingly, the current… read more here.
Keywords: inflammation; cell; snhg16 oxidative; oxidative stress ... See more keywords
CircSEC24A (hsa_circ_0003528) interference suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells via miR-421/MMP3 axis.
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2057761
Abstract: Accumulating evidence indicates that circular RNAs (circRNAs) function as conclusive modulators in diverse tumors, including in hepatocellular carcinoma (HCC). Nonetheless, knowledge of the latent mechanisms involving circRNAs in HCC development is insufficient. circSEC24A (hsa_circ_0003528) was… read more here.
Keywords: hepatocellular carcinoma; circsec24a; hcc; mmp3 ... See more keywords
Clinical role of miR-421 as a novel biomarker in diagnosis of gastric cancer patients
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029242
Abstract: Abstract Background: Gastric cancer (GC) has been identified as one of the most common malignancies. It was found that microRNAs can be used as potential biomarkers for GC diagnosis. The aim of this study was… read more here.
Keywords: dor auc; auc value; gastric cancer; mir ... See more keywords
Circular RNA_CNST Promotes the Tumorigenesis of Osteosarcoma Cells by Sponging miR-421
Sign Up to like & getrecommendations! Published in 2020 at "Cell Transplantation"
DOI: 10.1177/0963689720926147
Abstract: Circular RNAs (circRNAs) act crucial roles in the progression of multiple malignancies including osteosarcoma (OS). But, the underlying mechanisms by which hsa_circ_0017311 (circCNST) contributes to the tumorigenesis of OS remain poorly understood. Our present study… read more here.
Keywords: circcnst; sponging mir; osteosarcoma; promotes tumorigenesis ... See more keywords
N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer"
DOI: 10.1186/s12943-019-0941-2
Abstract: BackgroundMYCN amplification or N-Myc overexpression is found in approximately 40% NEPC and up to 20% CRPC patients. N-Myc has been demonstrated to drive disease progression and hormonal therapeutic resistance of NEPC/CRPC. Here, we aim to… read more here.
Keywords: therapeutic resistance; resistance; atm pathway; 421 atm ... See more keywords
MicroRNA-421 Inhibits Apoptosis by Downregulating Caspase-3 in Human Colorectal Cancer
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DOI: 10.2147/cmar.s255787
Abstract: Purpose Dysregulated microRNAs (miRNAs/miRs) have been reported to play significant roles in pathogenesis of colorectal cancer (CRC). Previous studies have demonstrated that miR-421 regulates apoptosis in some cancers. Caspase-3 plays a key role in apoptosis,… read more here.
Keywords: caspase; crc; apoptosis; mir 421 ... See more keywords
MiR-421 Binds to PINK1 and Enhances Neural Stem Cell Self-Renewal via HDAC3-Dependent FOXO3 Activation
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DOI: 10.3389/fcell.2021.621187
Abstract: Dysfunctions of neural stem cells (NSCs) often lead to a variety of neurological diseases. Thus, therapies based on NSCs have gained increasing attention recently. It has been documented that microRNA (miR)-421 represses the autophagy and… read more here.
Keywords: self renewal; mir 421; hdac3; nsc self ... See more keywords
MicroRNA-421-targeted PDCD4 regulates breast cancer cell proliferation
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2018.3932
Abstract: MicroRNAs (miRNAs) are expressed aberrantly in various types of cancer, and negatively regulate the expression of target genes which may be useful in therapeutic strategies in several biological processes. In the present study, the expression… read more here.
Keywords: 231 cells; mda 231; mcf mda; breast cancer ... See more keywords