A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202104759
Abstract: The H19X‐encoded miR‐424(322)/503 cluster regulates multiple cellular functions. Here, it is reported for the first time that it is also a critical linchpin of fat mass expansion. Deletion of this miRNA cluster in mice results… read more here.
Keywords: differentiation; 424 322; cluster; 322 503 ... See more keywords
MicroRNA‐424 regulates epithelial‐mesenchymal transition of endometrial carcinoma by directly targeting insulin‐like growth factor 1 receptor
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27528
Abstract: Although numerous miRNAs are reported to contribute to the carcinogenesis of malignant tumor, the specific role of miR‐424 in endometrial carcinoma is seldom reported. To explore the effect of miR‐424 on epithelial‐mesenchymal transition and its… read more here.
Keywords: factor; mir 424; endometrial carcinoma; transition ... See more keywords
miR-424-5p combined with miR-17-5p has high diagnostic efficacy for endometriosis
Sign Up to like & getrecommendations! Published in 2022 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-022-06492-6
Abstract: Endometriosis (EMT) is a chronic benign disease with high prevalence. This study investigated the diagnostic value of serum miR-17-5p, miR-424-5p, and their combined expressions for EMT. Total 80 EMT patients of reproductive age who underwent… read more here.
Keywords: diagnostic efficacy; mir 424; mir; mir mir ... See more keywords
miR-424 induces apoptosis in glioblastoma cells and targets AKT1 and RAF1 oncogenes from the ERBB signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174273
Abstract: Glioblastoma is a lethal and incurable cancer. Tumor suppressor miRNAs are promising gene therapy tools for cancer treatment. In silico, we predicted miR-424 as a tumor suppressor. It had several target genes from the epidermal… read more here.
Keywords: mir 424; target genes; glioblastoma; tumor suppressor ... See more keywords
miR-424-5p overexpression inhibits LPS-stimulated inflammatory response in bovine endometrial epithelial cells by targeting IRAK2.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2021.103471
Abstract: Endometritis is inflammation of endometrium due to various factors and is a common cause of infertility. Several remedies used for endometritis like antibiotics, hormones, and herbs. Studies confirm that microRNAs play a significant role in… read more here.
Keywords: response bovine; bovine endometrial; endometrial epithelial; mir 424 ... See more keywords
MicroRNA-424-5p acts as a potential biomarker and inhibits proliferation and invasion in hepatocellular carcinoma by targeting TRIM29.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.03.028
Abstract: BACKGROUND miRNA-424-5p (miR-424-5p) has been implicated in the development and progression of various tumors. However, the functional mechanisms of miR-424-5p in hepatocellular carcinoma (HCC) are unclear. In this study, we investigated the specific biological functions… read more here.
Keywords: mir 424; hcc; proliferation invasion; proliferation ... See more keywords
Potential role of microRNA-424 in regulating ERRγ to suppress trophoblast proliferation and invasion in fetal growth restriction.
Sign Up to like & getrecommendations! Published in 2019 at "Placenta"
DOI: 10.1016/j.placenta.2019.07.001
Abstract: BACKGROUND Abnormal expression of estrogen-related receptor γ (ERRγ) protein is associated with fetal growth restriction (FGR). The upstream regulators of ERRγ are still unknown. OBJECTIVE To evaluate the placental expression level of microRNA-424 (miR-424) and… read more here.
Keywords: expression; err; mir 424; invasion ... See more keywords
Downregulation of miR-424 in placenta is associated with severe preeclampsia.
Sign Up to like & getrecommendations! Published in 2019 at "Pregnancy hypertension"
DOI: 10.1016/j.preghy.2019.05.017
Abstract: Previous studies have suggested that altered miRNA expression in the placenta is associated with preeclampsia. The aim of this study was to investigate the expression of miR-424 in placental samples of severe preeclampsia (sPE) and… read more here.
Keywords: expression; placenta associated; mir 424; severe preeclampsia ... See more keywords
Knockdown of lncRNA SNHG1 alleviates oxygen-glucose deprivation/reperfusion-induced cell death by serving as a ceRNA for miR-424 in SH-SY5Y cells
Sign Up to like & getrecommendations! Published in 2020 at "Neurological Research"
DOI: 10.1080/01616412.2019.1672389
Abstract: ABSTRACT Objective: Long non-coding RNAs (lncRNAs) are theorized to serve a critical role in cerebral ischemia/reperfusion injury. The purpose of this study was to determine whether knockdown of lncRNA SNHG1 protected against oxygen-glucose deprivation/reperfusion (OGD/R)-induced… read more here.
Keywords: lncrna snhg1; mir 424; cell; sy5y cells ... See more keywords
Suppression of MicroRNA 424 Levels by Human Papillomaviruses Is Necessary for Differentiation-Dependent Genome Amplification
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01712-17
Abstract: ABSTRACT High-risk human papillomaviruses (HPVs) link their life cycle to epithelial differentiation and require activation of DNA damage pathways for efficient replication. HPVs modulate the expression of cellular transcription factors, as well as cellular microRNAs… read more here.
Keywords: mir 424; 424 levels; differentiation; hpv positive ... See more keywords
THU0203 PROMOTER DNA METHYLATION AND HSA-MIR-424-5P REGULATE ATF6 ALPHA EXPRESSION IN SALIVARY GLANDS OF PATIENTS WITH SJÖGREN’S SYNDROME
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.4712
Abstract: Background: Salivary glands (SG) from Sjögren’s syndrome (SS)-patients show chronic inflammation and endoplasmic reticulum (ER) stress. To counteract ER stress, eukaryotic cells activate adaptive mechanisms referred to as the unfolded protein response via sensors present… read more here.
Keywords: methylation; mir 424; dna; hsa mir ... See more keywords