MiR-448 promotes vascular smooth muscle cell proliferation and migration in through directly targeting MEF2C
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-9771-1
Abstract: Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) is a critical process in various cardiovascular diseases such as coronary artery disease (CAD), atherosclerosis, stroke, and hypertension. MicroRNAs (miRNAs) are small, short, and noncoding… read more here.
Keywords: proliferation migration; mef2c; proliferation; mir 448 ... See more keywords
KDM5B-mediated microRNA-448 up-regulation restrains papillary thyroid cancer cell progression and slows down tumor growth via TGIF1 repression.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117519
Abstract: OBJECTIVE Papillary thyroid cancer (PTC) is the most ordinary type of thyroid cancer. Studies pivoting on the mechanisms of microRNAs (miRNAs) are adequately explored but not much on miR-448 in PTC. Thus, this study is… read more here.
Keywords: cell progression; mir 448; ptc; growth ... See more keywords
Circulating miR-448 acts as a potential diagnostic biomarker for multiple myeloma
Sign Up to like & getrecommendations! Published in 2022 at "Hematology"
DOI: 10.1080/16078454.2022.2106818
Abstract: ABSTRACT Objective The current diagnostic methods for multiple myeloma (MM) include bone marrow aspiration and biopsy, which are not only complicated but also invasive, causing great pain to patients. Micro ribonucleotides (miRNA) exist stably in… read more here.
Keywords: circulating mir; mir 448; expression; acts potential ... See more keywords
LncRNA MCM3AP-AS1 is downregulated in atherosclerosis and sponges miR-448 to suppress vascular smooth muscle cell proliferation
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000033731
Abstract: Long noncoding RNA MCM3AP-AS1 plays critical roles in cancers, but its role in atherosclerosis is yet to be elucidated. The expression of MCM3AP-AS1 in atherosclerosis and control plasma samples were measured by RT-qPCR. IntaRNA was… read more here.
Keywords: mir 448; mcm3ap as1; atherosclerosis; proliferation ... See more keywords
KDM5B promotes self‐renewal of hepatocellular carcinoma cells through the microRNA‐448–mediated YTHDF3/ITGA6 axis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16342
Abstract: Histone methylation plays important roles in mediating the onset and progression of various cancers, and lysine‐specific demethylase 5B (KDM5B), as a histone demethylase, is reported to be an oncogene in hepatocellular carcinoma (HCC). However, the… read more here.
Keywords: hcc; itga6 axis; ythdf3 itga6; kdm5b ... See more keywords
The antitumor effect of miR-448 in epithelial ovarian cancer
Sign Up to like & getrecommendations! Published in 2020 at "Translational cancer research"
DOI: 10.21037/tcr-20-2464
Abstract: Ovarian cancer (OC) is the seventh most commonly diagnosed cancer in world and the tenth most common in China (1). OC accounts for an estimated 239,000 annual new cases and 152,000 deaths worldwide (2). Although… read more here.
Keywords: antitumor effect; effect mir; mir 448; ovarian cancer ... See more keywords
Inhibition of miR-448-3p Attenuates Cerebral Ischemic Injury by Upregulating Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2)
Sign Up to like & getrecommendations! Published in 2021 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s310495
Abstract: Background Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator responsible for oxidative stress in brain injury. This study aimed to investigate the potential mechanism of miR-448-3p and Nrf2 in cerebral ischemia/reperfusion (I/R)… read more here.
Keywords: erythroid related; factor erythroid; mir 448; nuclear factor ... See more keywords
LncRNA XIST regulates cell proliferation, migration and invasion of glioblastoma via regulating miR-448 and ROCK1.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of biological regulators and homeostatic agents"
DOI: 10.23812/20-558-l
Abstract: Long non-coding ribonucleic acids (lncRNAs) have been recognized as markers in several cancers and play important roles in glioblastoma (GBM). But the role of lncRNA X inactive-specific transcript (XIST) in GBM and its possible mechanisms… read more here.
Keywords: cell proliferation; mir 448; migration invasion; rock1 ... See more keywords
Effect of glycolysis inhibition by miR-448 on glioma radiosensitivity.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neurosurgery"
DOI: 10.3171/2018.12.jns181798
Abstract: OBJECTIVEAlthough glucose metabolism reengineering is a typical feature of various tumors, including glioma, key regulators of glycolytic reprogramming are still poorly understood. The authors sought to investigate whether glycolysis inhibition by microRNA (miR)-448 increases radiosensitivity… read more here.
Keywords: glioma; glycolysis inhibition; glioma radiosensitivity; mir 448 ... See more keywords
Downregulation of microRNA-448 improves isoflurane-induced learning and memory impairment in rats.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.6724
Abstract: The present study aimed to investigate the potential role of microRNA‑448 (miR‑448) in isoflurane-induced learning and memory impairment in rats. Sprague‑Dawley rats were used for the construction of isoflurane‑treated models. The Morris water maze test… read more here.
Keywords: memory impairment; learning memory; isoflurane induced; mir 448 ... See more keywords
MicroRNA-448 suppresses metastasis of pancreatic ductal adenocarcinoma through targeting JAK1/STAT3 pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology reports"
DOI: 10.3892/or.2017.5781
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is the most common type of malignant pancreatic tumor. MicroRNAs (miRNAs) are a group of small, non-protein coding, endogenous RNAs that play critical roles in tumorigenesis and progression of PDAC. In… read more here.
Keywords: stat3 pathway; mir 448; jak1 stat3; pdac ... See more keywords