Overexpression of TUSC7 inhibits the inflammation caused by microglia activation via regulating miR-449a/PPAR-γ.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.06.111
Abstract: OBJECTIVE The aim of this study was to investigate the mechanisms of TUSC7/miR-449a/PPAR-γ axis on the inflammation induced by microglia activation. METHODS A compressive spinal cord injury (SCI) model was established. The expressions of TUSC7,… read more here.
Keywords: mir 449a; overexpression tusc7; 449a ppar; activation ... See more keywords
Circular RNA CDK6 suppresses cervical cancer proliferation and metastasis by sponging miR-449a
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2036898
Abstract: ABSTRACT Cervical cancer is a malignant tumor that severely threatens female health. Recently, more and more studies indicated that circRNA could function as a tumor activator or suppressor in cervical cell development. Therefore, we aimed… read more here.
Keywords: cervical cancer; mir 449a; proliferation metastasis; circcdk6 ... See more keywords
Silencing of long chain noncoding RNA paternally expressed gene (PEG10) inhibits the progression of neuroblastoma by regulating microRNA-449a (miR-449a)/ribosomal protein S2 (RPS2) axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2042999
Abstract: ABSTRACT To investigate the mechanism of paternally expressed gene (PEG10) in regulating neuroblastoma (NB) progression. PEG10 expression was detected using quantitative real-time reverse transcription polymerase-chain reaction (qRT-PCR). The interaction of miR-449a and PEG10 or ribosomal… read more here.
Keywords: mir 449a; proliferation migration; peg10; invasion ... See more keywords
miR-449a: a potential therapeutic agent for cancer
Sign Up to like & getrecommendations! Published in 2017 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000000555
Abstract: MicroRNAs (miRNAs) have been reported to be associated with cancer progression and carcinogenesis. They are small, highly conserved, noncoding RNA molecules consisting of 19–25 nucleotides. By binding to complementary binding sites within the 3′-untranslated region… read more here.
Keywords: mir 449a; therapeutic agent; potential therapeutic; cancer ... See more keywords
circRNA mannosidase alpha class 1A member 2 contributes to the proliferation and motility of papillary thyroid cancer cells through upregulating metadherin via absorbing microRNA-449a
Sign Up to like & getrecommendations! Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001340
Abstract: Papillary thyroid carcinoma (PTC) is a common malignancy in endocrine system globally. Accumulating articles have found that circular RNAs (circRNAs) were dysregulated, and they were involved in PTC development. The aim of this project was… read more here.
Keywords: mir 449a; circman1a2; proliferation; ptc ... See more keywords
Circulating miR-449a predicts survival outcome for colorectal cancer following curative resection
Sign Up to like & getrecommendations! Published in 2021 at "Medicine"
DOI: 10.1097/md.0000000000025022
Abstract: Abstract Previous studies showed that microRNA (miR)-449a may function as a tumor suppressor. However, the expression pattern and value of circulating miR-449a in colorectal cancer (CRC) remain unclear. Therefore, the purpose of this study was… read more here.
Keywords: 449a level; crc; mir 449a; colorectal cancer ... See more keywords
MicroRNA-449a Is Downregulated in Cervical Cancer and Inhibits Proliferation, Migration, and Invasion
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Research and Treatment"
DOI: 10.1159/000502122
Abstract: Introduction: Cervical cancer is one of the most common malignant tumors among women in the world. MicroRNA-449a (miR-449a) has been identified as a tumor suppressor gene in various cancers. Our present study aimed to explore… read more here.
Keywords: proliferation migration; mir 449a; cervical cancer; cancer ... See more keywords
MALAT1: A Pivotal lncRNA in the Phenotypic Switch of Gastric Smooth Muscle Cells via the Targeting of the miR-449a/DLL1 Axis in Diabetic Gastroparesis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.719581
Abstract: Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus (DM). Our previous study suggested that the expression of the long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is closely related to DGP.… read more here.
Keywords: phenotypic switch; mir 449a; 449a dll1; malat1 ... See more keywords
A Boolean Model of the Proliferative Role of the lncRNA XIST in Non-Small Cell Lung Cancer Cells
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DOI: 10.3390/biology11040480
Abstract: Simple Summary The lncRNA XIST has been verified as an oncogenic gene in non-small cell lung cancer (NSCLC), whereas the tumor suppressors miR-34a, miR-449a, and miR-16 were downregulated in NSCLC. The lncRNA XIST is known… read more here.
Keywords: lncrna xist; mir; mir 449a; cell ... See more keywords
Mus musculus-microRNA-449a ameliorates neuropathic pain by decreasing the level of KCNMA1 and TRPA1, and increasing the level of TPTE.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.6559
Abstract: Neuropathic pain is a nerve disorder characterized by the dysregulation of ion channels in dorsal root ganglion (DRG) neurons. MicroRNAs (miRs) may be associated with the molecular mechanisms underlying the altered levels of ion channels; however,… read more here.
Keywords: mir 449a; mus musculus; mmu mir; level ... See more keywords
Analysis of Differentially Expressed Proteins Involved in miR-449a for Hepatocellular Carcinoma by iTRAQ Proteomics.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical laboratory"
DOI: 10.7754/clin.lab.2020.200628
Abstract: BACKGROUND To investigate the relationship between down-regulation of miR-449a and prognosis of hepatocellular carcinoma (HCC) and to elucidate the potential target proteins of miR-449a. MATERIAL AND METHODS The expression of miR-449a in 142 HCC tissues… read more here.
Keywords: hepatocellular carcinoma; hcc; expression group; mir 449a ... See more keywords