miR-122 and the WNT/β-catenin pathway inhibit effects of both interleukin-1β and tumor necrosis factor-α in articular chondrocytes in vitro.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30244
Abstract: Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and WNT/β-catenin signaling cause dysregulation of rat primary articular chondrocytes (rArCs), resulting in cartilage extracellular matrix destruction and osteoarthritis (OA) progression. microRNA (miR) miR-122 represses these effects whereas miR-451… read more here.
Keywords: mmp pge2; mir 451; wnt catenin; pge2 production ... See more keywords
hUC‐MSCs exosomal miR‐451 alleviated acute lung injury by modulating macrophage M2 polarization via regulating MIF‐PI3K‐AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23639
Abstract: In the previous study, we have proved that exosomal miR‐451 from human umbilical cord mesenchymal stem cells (hUC‐MSCs) attenuated burn‐induced acute lung injury (ALI). However, the mechanism of exosomal miR‐451 in ALI remains unclear. Therefore,… read more here.
Keywords: mir 451; macrophage polarization; huc mscs; exosomal mir ... See more keywords
Altered Expression of CD44, SIRT1, CXCR4, miR-21, miR-34a, and miR-451 Genes in MKN-45 Cell Line After Docetaxel Treatment
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastrointestinal Cancer"
DOI: 10.1007/s12029-019-00274-1
Abstract: Purpose Today it is known that the gene expression profile of cancer stem cells differs from other cancer cells, which may lead to the resistance to routine treatments. The aim of this study was to… read more here.
Keywords: sirt1 cxcr4; mir 34a; mir; cd44 ... See more keywords
Effects of clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) protein 9 system-Based Deletion of miR-451 in Mouse Embryonic Stem Cells on Their Self-Renewal and Hematopoietic Differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Tissue Engineering and Regenerative Medicine"
DOI: 10.1007/s13770-017-0031-8
Abstract: Pluripotent stem cells (PSCs) are a useful source of cells for exploring the role of genes related with early developmental processes and specific diseases due to their ability to differentiate into all somatic cell types.… read more here.
Keywords: system; crispr; clustered regularly; regularly interspaced ... See more keywords
The tumour suppressor effects and regulation of cancer stem cells by macrophage migration inhibitory factor targeted miR-451 in colon cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.02.046
Abstract: BACKGROUND This study aimed to investigate the impact of miR-451 on the biological behaviours of colon cancer cells along with its targets interactions. METHOD The levels of miR-451 were tested in colon cancer cell lines… read more here.
Keywords: 451 colon; colon cancer; mir 451; cancer cells ... See more keywords
Ago2-Dependent Processing Allows miR-451 to Evade the Global MicroRNA Turnover Elicited during Erythropoiesis.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.02.020
Abstract: MicroRNAs (miRNAs) are sequentially processed by two RNase III enzymes, Drosha and Dicer. miR-451 is the only known miRNA whose processing bypasses Dicer and instead relies on the slicer activity of Argonaute-2 (Ago2). miR-451 is… read more here.
Keywords: processing; ago2 dependent; dependent processing; dicer ... See more keywords
Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02152-x
Abstract: Autism spectrum disorders (ASD) are characterized by a wide genetic and clinical heterogeneity. However, some biochemical impairments, including decreased melatonin (crucial for circadian regulation) and elevated platelet N-acetylserotonin (the precursor of melatonin) have been reported… read more here.
Keywords: spectrum disorders; melatonin synthesis; mir 451; melatonin ... See more keywords
Downregulation of miR-451 in Tunisian chronic myeloid leukemia patients: potential implication in imatinib resistance
Sign Up to like & getrecommendations! Published in 2017 at "Hematology"
DOI: 10.1080/10245332.2016.1252020
Abstract: ABSTRACT Objectives: Resistance to imatinib has been recognized as a major challenge for the treatment of chronic myeloid leukemia (CML). Aberrant expression of miR-451 has been reported to participate in anticancer drug resistance. However, the… read more here.
Keywords: cml; imatinib resistance; resistance; chronic myeloid ... See more keywords
MiR-451 Promotes Cell Proliferation and Metastasis in Pancreatic Cancer through Targeting CAB39
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/2381482
Abstract: Emerging evidence shows that microRNAs (miRNAs) play important roles in the regulation of various biological and pathologic processes in human cancers and the aberrant expression of miRNAs contributes to the tumor development. In this study,… read more here.
Keywords: cell viability; pancreatic cancer; metastasis; mir 451 ... See more keywords
miR-451 on Myocardial Ischemia-Reperfusion in Rats by Regulating AMPK Signaling Pathway
Sign Up to like & getrecommendations! Published in 2021 at "BioMed Research International"
DOI: 10.1155/2021/9933998
Abstract: Myocardial infarction is the main cause of death in patients with coronary heart disease. At present, the main method to treat cardiovascular disease is perfusion therapy. Myocardial ischemia-reperfusion will inevitably lead to reperfusion injury, which… read more here.
Keywords: myocardial ischemia; reperfusion; mir 451; ischemia reperfusion ... See more keywords
MiR-7-5pand miR-451 as diagnostic biomarkers for papillary thyroid carcinoma in formalin-fixed paraffin-embedded tissues.
Sign Up to like & getrecommendations! Published in 2020 at "Die Pharmazie"
DOI: 10.1691/ph.2020.0335
Abstract: MiR-7-5p and miR-451 are important members of the small RNA family, which have been shown to be significantly downregulated in various human tumors and play a key role in the occurrence and development of tumors.… read more here.
Keywords: fixed paraffin; mir mir; mir; formalin fixed ... See more keywords