microRNA‐486‐5p is implicated in the cisplatin‐induced apoptosis and acute inflammation response of renal tubular epithelial cells by targeting HAT1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23039
Abstract: The proinflammatory property of cisplatin is potentially destructive and contributes to the pathogenesis of acute kidney injury (AKI). The role and upstream regulatory mechanism of histone acetyltransferase 1 (HAT1) in acute kidney inflammation are still… read more here.
Keywords: inflammation; cisplatin induced; hat1; tubular epithelial ... See more keywords
Circular RNA hsa_circ_0016788 regulates hepatocellular carcinoma tumorigenesis through miR‐486/CDK4 pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26612
Abstract: Recent studies have revealed that circular RNAs (circRNAs) play important roles in the tumorigenesis of human cancer, including hepatocellular carcinoma (HCC). In present study, we screen the circular RNA expression profiles in HCC tissue and… read more here.
Keywords: circ 0016788; hsa circ; cdk4; mir 486 ... See more keywords
miR‐486‐3p regulates CyclinD1 and promotes fluoride‐induced osteoblast proliferation and activation
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Toxicology"
DOI: 10.1002/tox.23302
Abstract: Fluoride is a persistent environmental pollutant, and its excessive intake contributes to skeletal and dental fluorosis. The mechanisms underlying fluoride‐induced abnormal osteoblast proliferation and activation, which are related to skeletal fluorosis, have not yet been… read more here.
Keywords: fluoride induced; proliferation activation; mir 486; osteoblast proliferation ... See more keywords
miR-486 is involved in the pathogenesis of acute myeloid leukemia by regulating JAK-STAT signaling
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01892-4
Abstract: Acute myeloid leukemia (AML) is a widely prevalent disease worldwide and poses a large threat to public health. Previous studies have shown that AML is associated with cytogenetic heterogeneity, complex subtypes, and different therapeutic approaches.… read more here.
Keywords: myeloid leukemia; involved pathogenesis; mir 486; acute myeloid ... See more keywords
micro-RNA-486-5p protects against kidney ischemic injury and modifies the apoptotic transcriptome in proximal tubules.
Sign Up to like & getrecommendations! Published in 2021 at "Kidney international"
DOI: 10.1016/j.kint.2021.05.034
Abstract: Acute kidney injury (AKI) carries high morbidity and mortality, and effective treatments are lacking. Preclinical models support involvement of micro-RNAs (miRs) in AKI pathogenesis, although effects on the kidney transcriptome are unclear. We previously showed… read more here.
Keywords: aki; ischemic injury; injury; proximal tubules ... See more keywords
MiR-92a and miR-486 are potential diagnostic biomarkers for mercury poisoning and jointly sustain NF-κB activity in mercury toxicity
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13230-5
Abstract: Occupational and environmental exposure to mercury is a public health concern worldwide. Although the altered epigenetic regulatory features, such as microRNA, have been associated with mercury exposure, the underlying molecular mechanism is not well illuminated.… read more here.
Keywords: mercury poisoning; mir 92a; mir 486; 92a mir ... See more keywords
MiR-486-5p inhibits the hyperproliferation and production of collagen in hypertrophic scar fibroblasts via IGF1/PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Dermatological Treatment"
DOI: 10.1080/09546634.2020.1728210
Abstract: Abstract Background This study explored the function and mechanism of miR-486-5p in HSFBs. Methods Qualitative real-time-polymerase chain reaction (qRT-PCR) was performed to detect the expression of miR-486-5p in HS and hypertrophic scar fibroblasts (HSFBs). Viability,… read more here.
Keywords: collagen; pi3k akt; hsfbs; igf1 ... See more keywords
Identification of a novel circular RNA circZNF652/miR-486-5p/SERPINE1 signaling cascade that regulates cancer aggressiveness in glioblastoma (GBM)
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DOI: 10.1080/21655979.2021.2018096
Abstract: ABSTRACT Circular RNAs (circRNAs) are closely associated with cancer development in glioblastoma (GBM), and this study aims to explore the molecular mechanisms of a novel circular RNA circZNF652 in regulating GBM aggressiveness. The present study… read more here.
Keywords: serpine1; circular rna; circznf652; rna circznf652 ... See more keywords
Long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 gene (PVT1) modulates the proliferation and apoptosis of acute lymphoblastic leukemia cells by sponging miR-486-5p
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DOI: 10.1080/21655979.2022.2031405
Abstract: ABSTRACT Long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 gene (PVT1) is related to the progress of various cancers. Here, we illuminated the role of PVT1 in acute lymphoblastic leukemia (ALL) cell proliferation and apoptosis.… read more here.
Keywords: cell; mir 486; pvt1; proliferation apoptosis ... See more keywords
miR-486-5p Restrains Extracellular Matrix Production and Oxidative Damage in Human Trabecular Meshwork Cells by Targeting TGF-β/SMAD2 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Ophthalmology"
DOI: 10.1155/2022/3584192
Abstract: Background Glaucoma is characterized by elevated intraocular pressure caused by aqueous outflow dysfunction. Trabecular meshwork plays a key role in controlling intraocular pressure by modulating aqueous outflow. This study investigated the protective effects of miR-486-5p… read more here.
Keywords: h2o2; oxidative damage; tgf smad2; mir 486 ... See more keywords
miR-486 is modulated by stretch and increases ventricular growth
Sign Up to like & getrecommendations! Published in 2019 at "JCI Insight"
DOI: 10.1172/jci.insight.125507
Abstract: Perturbations in biomechanical stimuli during cardiac development contribute to congenital cardiac defects such as hypoplastic left heart syndrome (HLHS). This study sought to identify stretch-responsive pathways involved in cardiac development. miRNA-Seq identified miR-486 as being… read more here.
Keywords: stretch; 486 modulated; stretch increases; growth ... See more keywords