MicroRNA-489-3p attenuates neuropathic allodynia by regulating oncoprotein DEK/TET1-dependent epigenetic modification in the dorsal horn
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2022.109028
Abstract: Originally characterized as an oncoprotein overexpressed in many forms of cancer that participates in numerous cellular pathways, DEK has since been well described regarding the regulation of epigenetic markers and transcription factors in neurons. However,… read more here.
Keywords: dek tet1; dek; neuropathic allodynia; mir 489 ... See more keywords
Long intergenic non-protein coding RNA 115 (LINC00115) aggravates retinoblastoma progression by targeting microRNA miR-489-3p that downregulates 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2)
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2037362
Abstract: ABSTRACT Long non-coding RNAs (lncRNAs) are key regulators of cancer. However, the role of long intergenic non-protein coding RNA 115 (LINC00115) in the regulation of retinoblastoma (RB) has not yet been studied. The expression levels… read more here.
Keywords: intergenic non; non protein; long intergenic; pfkfb2 ... See more keywords
MicroRNA-489-3p aggravates neuronal apoptosis and oxidative stress after cerebral ischemia-reperfusion injury
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DOI: 10.1080/21655979.2022.2062534
Abstract: ABSTRACT Cerebral ischemia-reperfusion injury (CIRI) mostly occurs in the treatment stage of ischemic diseases and aggravate brain tissue damage. Although studies have demonstrated that miR-489-3p is closely related to CIRI, the effects of miR-489-3p on… read more here.
Keywords: oxidative stress; brain; injury; sirt1 ... See more keywords
6′-O-Galloylpaeoniflorin Exerts Inhibitory Bioactivities in Human Neuroblastoma Cells via Modulating AMPK/miR-489/XIAP Pathway
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/1327835
Abstract: Although therapies against neuroblastoma (NBM) have advanced, the patients still suffer from poor prognoses due to distal metastasis or the occurrence of multidrug resistance. Accumulating evidence has proved that chemicals derived from natural products possess… read more here.
Keywords: cells via; ampk mir; xiap pathway; anti nbm ... See more keywords
Abstract 3424: Role of miR-489 in mammary gland development and Her2 mediated tumorigenesis
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-3424
Abstract: HER2 overexpression is linked with poor prognosis and outcome in breast cancer. In our previous study, we have found miR-489 was specifically down regulated by HER2 overexpression. Restoration of miR-489 in multiple breast cancer cell… read more here.
Keywords: mmtv mir; mammary gland; mice; mir 489 ... See more keywords
MiR-489 inhibited the development of gastric cancer via regulating HDAC7 and PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Surgical Oncology"
DOI: 10.1186/s12957-020-01846-3
Abstract: Background Mounting evidences have displayed that the dysregulation of miRNAs plays important roles in the pathogenesis of gastric cancer (GC). The purpose of this study was to explore the biological functions and potential mechanism of… read more here.
Keywords: hdac7; gastric cancer; pi3k akt; mir 489 ... See more keywords
Long Non-coding RNA LINC00115 Contributes to the Progression of Colorectal Cancer by Targeting miR-489-3p via the PI3K/AKT/mTOR Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.567630
Abstract: Long non-coding RNAs (lncRNAs) are tumor-related regulators and have been found to be involved in the underlying molecular mechanisms of colorectal cancer (CRC). However, the role of lncRNA LINC00115 during CRC progression is not entirely… read more here.
Keywords: mir 489; linc00115; colorectal cancer; long non ... See more keywords
Therapeutic Potential of Chemically Modified miR-489 in Triple-Negative Breast Cancers
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DOI: 10.3390/cancers12082209
Abstract: Triple-negative breast cancers (TNBCs) lack ER, PR and her2 receptors that are targets of common breast cancer therapies with poor prognosis due to their high rates of metastasis and chemoresistance. Based on our previous studies… read more here.
Keywords: negative breast; breast cancers; tnbc; mir 489 ... See more keywords
miR-489 promotes apoptosis and inhibits invasiveness of glioma cells by targeting PAK5/RAF1 signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Reports"
DOI: 10.3892/or.2019.7381
Abstract: Glioma patients receiving therapy are at a high risk of relapse and rapid progression and, thus, more effective treatments are required. The aim of the present study was to determine the suppressive role of miR-489… read more here.
Keywords: raf1; glioma; pak5; expression ... See more keywords
IL-1β-Triggered Long Non-coding RNA CHRF Induces Non-Small Cell Lung Cancer by Modulating the microRNA-489/Myd88 Axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer"
DOI: 10.7150/jca.63256
Abstract: Background: Long noncoding RNAs (LncRNAs) possess crucial roles in carcinogenesis. The current study aims to evaluate the effects of interleukin-1β (IL-1β)-mediated lncRNA cardiac hypertrophy-related factor (CHRF)/microRNA-489 (miR-489)/myeloid differentiation factor 88 (Myd88) on non-small-cell lung cancer… read more here.
Keywords: cell; 489 myd88; lncrna chrf; mir 489 ... See more keywords