Polycomb complex mediated epigenetic reprogramming alters TGF‐β signaling via a novel EZH2/miR‐490/TGIF2 axis thereby inducing migration and EMT potential in glioblastomas
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DOI: 10.1002/ijc.32360
Abstract: Recent advancement in understanding cancer etiology has highlighted epigenetic deregulation as an important phenomenon leading to poor prognosis in glioblastoma (GBM). Polycomb repressive complex 2 (PRC2) is one such important epigenetic modifier reportedly altered in… read more here.
Keywords: mir 490; migration emt; gbm; polycomb ... See more keywords
Targeting the MicroRNA-490-3p-ATG4B-Autophagy Axis Relieves Myocardial Injury in Ischemia Reperfusion
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DOI: 10.1007/s12265-020-09972-9
Abstract: We investigated the potential role of miR-490-3p in ischemia reperfusion (IR) injury. We first determined the expression of miR-490-3p and autophagy-related 4B cysteine (ATG4B) in IR. Then, to explore whether miR-490-3p would affect autophagy, apoptosis,… read more here.
Keywords: mir 490; myocardial injury; autophagy; ischemia reperfusion ... See more keywords
Sevoflurane improves nerve regeneration and repair of neurological deficit in brain damage rats via microRNA-490-5p/CDK1 axis.
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DOI: 10.1016/j.lfs.2021.119111
Abstract: BACKGROUND Sevoflurane (Sevo) is neuroprotective in brain damage, thus our objective was to further investigate the impact of Sevo treatment on nerve regeneration and repair of neurological deficit in brain damage rats by regulating miR-490-5p… read more here.
Keywords: mir 490; repair neurological; damage rats; brain damage ... See more keywords
Long non-coding RNA AL139002.1 promotes gastric cancer development by sponging microRNA-490-3p to regulate Hepatitis A Virus Cellular Receptor 1 expression.
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DOI: 10.1080/21655979.2021.1922329
Abstract: Mounting evidence suggests that lncRNA regulates many important diseases. However, the biological role of most lncRNAs in gastric cancer (GC) remain unclear. In this paper, we determined differential expression of lncRNAs and predicted ceRNA networks… read more here.
Keywords: lncrna al139002; mir 490; gastric cancer; expression ... See more keywords
MicroRNA MiR-490-5p suppresses pancreatic cancer through regulating epithelial-mesenchymal transition via targeting MAGI2 antisense RNA 3
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DOI: 10.1080/21655979.2021.2024653
Abstract: ABSTRACT Pancreatic cancer with about 5% five-year overall survival rate remains a challenge. Invasion and migration of pancreatic cancer cells are the main factors leading to poor prognosis. MicroRNA-490-5p (miR-490-5p) has anti-cancer effects in a… read more here.
Keywords: mir 490; magi2 as3; antisense rna; pancreatic cancer ... See more keywords
Exosomal circRNA FNDC3B promotes the progression of esophageal squamous cell carcinoma by sponging miR-490-5p and regulating thioredoxin reductase 1 expression
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DOI: 10.1080/21655979.2022.2084484
Abstract: ABSTRACT Exosomal circular RNAs (circRNAs) have been reported to play critical roles in esophageal squamous cell carcinoma (ESCC). We aimed to investigate the function of exosomal circRNA FNDC3B (circFNDC3B). The RNA levels and protein levels… read more here.
Keywords: mir 490; cell; circfndc3b; squamous cell ... See more keywords
CircPVT1 promotes migration and invasion by regulating miR‐490‐5p/ HAVCR2 axis in osteosarcoma cells
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DOI: 10.1111/jcmm.18269
Abstract: Circular RNAs (circRNAs) play an important role in the progression of osteosarcoma. However, the precise function of circPVT1 in osteosarcoma remains elusive. This study aims to explore the molecular mechanism underlying the involvement of circPVT1… read more here.
Keywords: osteosarcoma; osteosarcoma cells; mir 490; migration invasion ... See more keywords
LINC00958 promotes bladder cancer carcinogenesis by targeting miR-490-3p and AURKA
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DOI: 10.1186/s12885-021-08882-6
Abstract: Background Bladder cancer is a prevalent malignancy of the urinary system, in which long non-coding RNAs (lncRNAs) are highly associated. We aimed to elucidate the role of LINC00958 in bladder cancer. Methods LINC00958 expression levels… read more here.
Keywords: bladder cancer; mir 490; linc00958; 490 aurka ... See more keywords
The lncRNA CCAT1 upregulates TGFβR1 via sponging miR-490-3p to promote TGFβ1-induced EMT of ovarian cancer cells
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DOI: 10.1186/s12935-018-0604-1
Abstract: BackgroundOvarian cancer is the fifth leading cause of cancer deaths in women worldwide. LncRNACCAT1 was reported to play a critical role in cell metastasis of ovarian cancer. However, little is known about the detailed mechanism… read more here.
Keywords: mir 490; ccat1; ovarian cancer; tgf induced ... See more keywords
LncRNA TONSL-AS1 regulates miR-490-3p/CDK1 to affect ovarian epithelial carcinoma cell proliferation
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DOI: 10.1186/s13048-020-00657-0
Abstract: Background LncRNA TONSL-AS1 has been characterized as a critical player in gastric cancer. By analyze the TCGA dataset, we observed the upregulation of TONSL-AS1 in ovarian epithelial carcinoma (EOC). We therefore investigated the involvement of… read more here.
Keywords: cdk1; mir 490; tonsl as1; eoc ... See more keywords
Changes in miRNA Pattern Expression Associated With COVID-19 Severity
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DOI: 10.21873/invivo.13852
Abstract: Background/Aim: Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 infection, manifests a wide range of clinical symptoms ranging from mild to moderate and severe. Host-related factors influence the course of SARS-CoV-2 infection; for instance, the expression… read more here.
Keywords: covid patients; changes mirna; mir 490; expression ... See more keywords