lncRNA H19 promotes glioblastoma multiforme development by activating autophagy by sponging miR-491-5p
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2065947
Abstract: ABSTRACT Glioblastoma multiforme (GBM) is a malignant cancer with severely poor survival, and the cells continue to thrive during hypoxia and toxic stress through autophagy. To validate the oncogenic role of long noncoding RNA H19… read more here.
Keywords: sponging mir; mir 491; h19; glioblastoma multiforme ... See more keywords
The Tumor Suppressor Roles and Mechanisms of MiR-491 in Human Cancers.
Sign Up to like & getrecommendations! Published in 2022 at "DNA and cell biology"
DOI: 10.1089/dna.2022.0274
Abstract: MicroRNAs (miRNAs) are short non-coding RNAs that bind to the 3' untranslated region (3'' UTR) of target mRNAs to control gene expression post-transcriptionally. Recent indications have highlighted their important roles in a variety of pathophysiological… read more here.
Keywords: tumor suppressor; mir 491; roles mechanisms; human cancers ... See more keywords
Plasma extracellular vesicle microRNA‐491‐5p as diagnostic and prognostic marker for head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Science"
DOI: 10.1111/cas.15067
Abstract: Poor survival of patients with locally advanced head and neck squamous cell carcinoma (LA‐HNSCC) is partly due to early diagnosis difficulties and the lack of reliable biomarkers for predicting treatment outcomes. In the discovery cohort,… read more here.
Keywords: neck squamous; mir 491; hnscc; marker ... See more keywords
Circ_0009910 sponges miR-491-5p to promote acute myeloid leukemia progression through modulating B4GALT5 expression and PI3K/AKT signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of laboratory hematology"
DOI: 10.1111/ijlh.13742
Abstract: BACKGROUND Acute myeloid leukemia (AML) is a heterogeneous group of leukemias with an overall poor prognosis. Circular RNAs (circRNAs) have been verified to play important regulatory roles in AML progression. However, the role and molecular… read more here.
Keywords: circ 0009910; mir 491; pi3k akt; aml cells ... See more keywords
The lncRNA-AK046375 Upregulates Metallothionein-2 by Sequestering miR-491-5p to Relieve the Brain Oxidative Stress Burden after Traumatic Brain Injury
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/8188404
Abstract: We previously discovered that traumatic brain injury (TBI) induces significant perturbations in long noncoding RNA (lncRNA) levels in the mouse cerebral cortex, and lncRNA-AK046375 is one of the most significantly changed lncRNAs after TBI. lncRNA-AK046375… read more here.
Keywords: traumatic brain; mir 491; brain; brain injury ... See more keywords
Interaction between linc01615 and miR-491-5p regulates the survival and metastasis of colorectal cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Translational cancer research"
DOI: 10.21037/tcr.2020.03.03
Abstract: Colorectal cancer (CRC) is the third most common cancer and fourth leading cause of cancer death worldwide. The incidence of CRC has been rapidly rising in many Asian countries in the past few decades (1).… read more here.
Keywords: mir 491; colorectal cancer; metastasis; linc01615 mir ... See more keywords
Ginsenoside Rh2 Inhibits Migration of Lung Cancer Cells Under Hypoxia via mir-491.
Sign Up to like & getrecommendations! Published in 2019 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520619666190704165205
Abstract: BACKGROUND Ginsenoside Rh2 (Rh2), which is extracted form ginseng, exerts antitumor activity. Here we would like to study the role of Rh2 on hypoxia-induced migration in lung adenocarcinoma. METHODS Lung adenocarcinoma A549 and H1299 cells… read more here.
Keywords: rh2; mir 491; migration; cancer ... See more keywords
MiR-491 suppresses migration and invasion via directly targeting TPX2 in breast cancer.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201911_19566
Abstract: OBJECTIVE Breast cancer (BC) is one of the primary causes of tumor-related female mortalities. Although in recent years, we have made great progress in the systemic therapy and earlier diagnosis for BC patients, recurrence or… read more here.
Keywords: invasion; mir 491; migration; breast cancer ... See more keywords
miR-491-5p inhibits Emilin 1 to promote fibroblasts proliferation and fibrosis in gluteal muscle contracture via TGF-?1/Smad2 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Physiological research"
DOI: 10.33549/physiolres.934804
Abstract: Gluteal muscle contracture (GMC) is a chronic fibrotic disease of gluteal muscles due to multiple etiologies. Emilin 1 plays a determinant role in fibers formation, but its role in the progression of GMC remains unclear.… read more here.
Keywords: mir 491; muscle contracture; gluteal muscle; fibrosis ... See more keywords
LncRNA MALAT1 Regulating Lung Carcinoma Progression via the miR-491-5p/UBE2C Axis
Sign Up to like & getrecommendations! Published in 2021 at "Pathology and Oncology Research"
DOI: 10.3389/pore.2021.610159
Abstract: Long noncoding RNAs (lncRNAs) play a critical role in the development of lung carcinoma. The mechanism of MALAT1 in lung carcinoma development is not understood very well. This study aimed to investigate the role of… read more here.
Keywords: carcinoma; mir 491; lung carcinoma; malat1 ... See more keywords
Network-Based Integration of Multi-Omics Data Identifies the Determinants of miR-491-5p Effects
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13163970
Abstract: Simple Summary The re-introduction of miRNAs with tumor-suppressor activity in cancer cells has not yet been implemented in clinical practice yet. However, the identification of miRNAs’ targets and associated regulatory networks might allow the definition… read more here.
Keywords: mir 491; network; ovarian cancer; multi omics ... See more keywords