MiR‐195 and miR‐497 suppress tumorigenesis in lung cancer by inhibiting SMURF2‐induced TGF‐β receptor I ubiquitination
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12581
Abstract: SMURF2 is a member of the HECT family of E3 ubiquitin ligases that have important roles as a negative regulator of transforming growth factor‐β (TGF‐β) signaling through ubiquitin‐mediated degradation of TGF‐β receptor I. However, the… read more here.
Keywords: 195 mir; mir 195; mir 497; smurf2 ... See more keywords
miR‐497 accelerates oxidized low‐density lipoprotein‐induced lipid accumulation in macrophages by repressing the expression of apelin
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biology International"
DOI: 10.1002/cbin.10808
Abstract: microRNAs (miRNAs) play important roles in the pathogenesis of atherosclerosis. A previous study has reported that miR‐497 is elevated in advanced atherosclerotic lesions in an apoE‐deficient (apoE‐/‐) mouse model. The purpose of this study is… read more here.
Keywords: lipid accumulation; apelin; mir; mir 497 ... See more keywords
Extracellular vesicle‐derived circ_SLC19A1 promotes prostate cancer cell growth and invasion through the miR‐497/septin 2 pathway
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11303
Abstract: The occurrence and development of prostate cancer (PCa) is complex, and the related mechanism is not fully understood. Current studies have found that extracellular vesicles (EVs) and circular RNAs (circRNAs) have important functions in various… read more here.
Keywords: slc19a1; mir 497; expression; circ slc19a1 ... See more keywords
TRPM2‐AS promotes paclitaxel resistance in prostate cancer by regulating FOXK1 via sponging miR‐497‐5p
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21924
Abstract: Chemoresistance seriously hinders the treatment efficiency of human cancers, including prostate cancer (PCa). Multiple long noncoding RNAs (lncRNAs) were involved in drug resistance in PCa. We aimed to explore the function of transient receptor potential… read more here.
Keywords: ptx resistant; mir 497; ptx; pca ... See more keywords
Inhibition of miR-497-3p Downregulates the Expression of Procalcitonin and Ameliorates Bacterial Pneumonia in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01279-w
Abstract: Pneumonia is usually caused by a wide variety of pathogen infection. The underlying mechanism contributing to pneumonia remains elusive. Here, the role of microRNA-497-3p (miR-497-3p) was explored in bacterial pneumonia. The expression levels of miR-497-3p… read more here.
Keywords: mir 497; bacterial pneumonia; mice; procalcitonin ... See more keywords
Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.02.014
Abstract: Evasion of apoptosis is a major contributing factor to the development of chemo- and radiotherapy resistance. Therefore, activation of non-apoptotic programmed cell death (PCD) could be an effective alternative against apoptosis-resistant cancers. In this study,… read more here.
Keywords: pyroptosis; targeting mir; pelp1; metformin induces ... See more keywords
LncRNA-PVT1 activates lung fibroblasts via miR-497-5p and is facilitated by FOXM1.
Sign Up to like & getrecommendations! Published in 2021 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2021.112030
Abstract: It is little known about the lncRNA-PVT1 effect on occupational pulmonary fibrosis, although researches show it plays an essential role in cancer. Studies reveal that lung fibroblast activation is one of the key events in… read more here.
Keywords: lncrna pvt1; lung fibroblasts; pvt1; mir 497 ... See more keywords
MicroRNA-497 inhibits inflammation in DSS-induced IBD model mice and lipopolysaccharide-induced RAW264.7 cells via Wnt/β-catenin pathway.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108318
Abstract: BACKGROUND AND AIMS MicroRNA (miR)-497 is downregulated in several inflammatory diseases, excluding inflammatory bowel disease (IBD). The aim of this study is to evaluate whether miR-497 inhibits gut inflammation both in vivo and in vitro.… read more here.
Keywords: inflammation; mir 497; pathway; mice ... See more keywords
Long non-coding RNA DLX6-AS1 regulates neuroblastoma progression by targeting YAP1 via miR-497-5p.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117657
Abstract: AIMS The lncRNA distal-less homeobox 6 antisense 1 (DLX6-AS1) has been reported to be an oncogenic lncRNA in diverse malignant cancers; however, whether it has oncogenic role in neuroblastoma(NB) remain largely unknown. This study explored… read more here.
Keywords: as1 regulates; mir 497; dlx6; expression ... See more keywords
Bone marrow mesenchymal stem cell-derived extracellular vesicles containing miR-497-5p inhibit RSPO2 and accelerate OPLL.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119481
Abstract: AIMS Muscle and adipose tissue-derived mesenchymal stem cells presented high osteogenic potentials, which modulate osteoblast function through releasing extracellular vesicles (EVs) containing miRNAs. Herein, this study evaluated the function of bone marrow mesenchymal stem cell-derived… read more here.
Keywords: extracellular vesicles; ligament fibroblasts; bmsc evs; mir 497 ... See more keywords
miR-497 promotes the migration and invasion of human medulloblast Daoy cell line through targeted regulation of ARHGDIA in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2022.136469
Abstract: OBJECTIVES To further investigate the effects of miR-497 on the biological behavior of human medulloblastoma cell line in vitro. METHODS Human medulloblastoma cell lines, Daoy and D341, were used in this study, and the miR-497… read more here.
Keywords: mir 497; arhgdia; daoy cells; migration invasion ... See more keywords