Propranolol inhibits EMT and metastasis in breast cancer through miR-499-5p-mediated Sox6
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-023-05599-w
Abstract: Purpose This study will focus on 4T1 cells, a murine mammary adenocarcinoma cell line, as the primary research subject. We aim to investigate the inhibitory effects and mechanisms of propranolol on epithelial–mesenchymal transition (EMT) in… read more here.
Keywords: propranolol; cancer; breast cancer; mir 499 ... See more keywords
Functional miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms and the susceptibility to hepatocellular carcinoma: An updated meta-analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2017.03.005
Abstract: OBJECTIVE Single nucleotide polymorphisms of miRNAs play important roles in the pathogenesis of hepatocellular carcinoma (HCC). To evaluate the association between four common miRNAs (miR-146a rs2910164; miR-149 rs2292832; miR-196a2 rs11614913 and miR-499 rs3746444) and HCC… read more here.
Keywords: mir 196a2; hcc; mir 149; mir 146a ... See more keywords
Comparison of miRNA signature versus conventional biomarkers before and after off‐pump coronary artery bypass graft
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2016.11.014
Abstract: HIGHLIGHTSPlasma microRNAs have advantages over conventional biomarkers for cardiac injuries.There is a strong correlation between plasma miR‐499 and cTnI in CABG patients.A strong correlation exists between plasma miR‐126 and uric acid in CABG patients.Release of… read more here.
Keywords: artery; mir 126; mir; conventional biomarkers ... See more keywords
Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499-5p/APC axis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2021.02.005
Abstract: Diabetic nephropathy is a serious complication of diabetes. Hyperoside has been widely reported to ameliorate diabetes-associated disease. The current study is designed to explore the mechanism of hyperoside in diabetic nephropathy. In the present study,… read more here.
Keywords: hyperoside ameliorates; apc; ameliorates diabetic; diabetic nephropathy ... See more keywords
Plasma miR-208b and miR-499: Potential Biomarkers for Severity of Coronary Artery Disease
Sign Up to like & getrecommendations! Published in 2019 at "Disease Markers"
DOI: 10.1155/2019/9842427
Abstract: Aims MicroRNAs (miRNAs) are associated with the pathogenesis of coronary artery disease (CAD). The objective of this study is to explore plasma levels of miR-208b and miR-499 in CAD and analyze its association with the… read more here.
Keywords: 208b mir; cad; mir 208b; mir 499 ... See more keywords
miR-499 in Platelet-Derived Extracellular Vesicles Augments Inflammatory Cell Generation and Cardiac Remodeling After Myocardial Infarction.
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circulationaha.124.073527
Abstract: BACKGROUND Emergency myelopoiesis by bone marrow hematopoietic stem and progenitor cells (HSPCs) exacerbates disease pathology in various chronic diseases, including myocardial infarction (MI) and atherosclerosis. However, the mechanisms triggering myelopoiesis in the bone marrow after… read more here.
Keywords: inflammatory cell; mir 499; cell generation; hspc ... See more keywords
Abstract 133: Exosomal Transfer of Muscle Specific Mir-499 to Endothelial and Endothelial Progenitor Cells Impairs Angiogenesis in Diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.133
Abstract: Background: miR-499, a muscle specific-miR, is enhanced in diabetic heart and has been suggested to be a therapeutic target for cardiovascular disease in diabetes. Recent studies provided the evidence that overexpressing miR-499 in ECs inhibits… read more here.
Keywords: muscle; tube formation; mir 499; muscle specific ... See more keywords
Abstract Thu167: Muscle-specific miR-499-5p delivered by small extracellular vesicles impairs endothelial function and ischemic hindlimb recovery in diabetic mice
Sign Up to like & getrecommendations! Published in 2025 at "Circulation Research"
DOI: 10.1161/res.137.suppl_1.thu167
Abstract: Background: Emerging evidence suggest that skeletal muscle cells (SKMC) play critical roles in the regulation of angiogenesis in diabetic critical limb ischemia with defective angiogenesis response. However, the molecular mechanisms linking skeletal muscle to impaired… read more here.
Keywords: mice; muscle; mir 499; angiogenesis ... See more keywords
Association of a MiR-499 SNP and risk of congenital heart disease in a Chinese population.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2018.64.10.17
Abstract: MicroRNAs (miRNAs) play an important role in heart development. Single nucleotide polymorphisms (SNPs) in miRNAs have been shown to associate with congenital heart disease (CHD). Methionine synthase (MTR), a key enzyme of folate metabolism, is… read more here.
Keywords: risk; chd; mir 499; congenital heart ... See more keywords
Exosomal miR-499a-5p Inhibits Endometrial Cancer Growth and Metastasis via Targeting VAV3
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Management and Research"
DOI: 10.2147/cmar.s283747
Abstract: Background/Aim The current therapeutic strategies for endometrial cancer are limited and unsatisfactory. Accumulating evidence suggest that microRNAs (miRNAs) participate in tumor growth and metastasis. Mesenchymal stem cells (MSCs) derived exosomes (Exos) are considered as better… read more here.
Keywords: growth; exosomal mir; cancer; endometrial cancer ... See more keywords
Expression of miR-208b and miR-499 in Greek Patients with Acute Myocardial Infarction.
Sign Up to like & getrecommendations! Published in 2018 at "In vivo"
DOI: 10.21873/invivo.11239
Abstract: BACKGROUND/AIM Certain microRNAs (miRs) present in human plasma are candidate biomarkers for cardiovascular diseases, including acute myocardial infarction (AMI). We examined the expression of two cardiac-specific miRs (miR-208b and miR-499) in a Greek pathological population.… read more here.
Keywords: 208b mir; mir; myocardial infarction; mir 208b ... See more keywords