MiR-503 pleiotropically regulates epithelial-mesenchymal transition and targets PTK7 to control lung cancer metastasis.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6116
Abstract: OBJECTIVE In lung cancer patients, most deaths are caused by the distant dissemination of cancer cells. Epithelial-mesenchymal transition (EMT) and collective cell migration are distinct and important mechanisms involved in cancer invasion and metastasis. Additionally,… read more here.
Keywords: lung cancer; cancer; cancer metastasis; mir 503 ... See more keywords
MicroRNA-503 Targets Mothers Against Decapentaplegic Homolog 7 Enhancing Hepatic Stellate Cell Activation and Hepatic Fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06460-7
Abstract: The hyper-accumulation of extracellular matrix (ECM) is the leading cause of hepatic fibrosis, and TGF-β-induced activation of hepatic stellate cells (HSCs) is the central event of hepatic fibrosis pathogenesis. The deregulation and dysfunction of miRNAs… read more here.
Keywords: overexpression; fibrosis; mir 503; tgf induced ... See more keywords
Implication of MicroRNA503 in Brain Endothelial Cell Function and Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2020 at "Translational Stroke Research"
DOI: 10.1007/s12975-020-00794-0
Abstract: The role of miR-503 in brain endothelium and ischemic stroke (IS) remains unclear. We aimed to study the relationship between plasma miR-503 and the onset time, severity, subtypes, and von Willebrand Factor (vWF) level in… read more here.
Keywords: mir 503; cell; brain; ischemic stroke ... See more keywords
Overexpression of hsa_circ_0022742 suppressed hyperglycemia-induced endothelial dysfunction by targeting the miR-503-5p/FBXW7 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Microvascular research"
DOI: 10.1016/j.mvr.2021.104249
Abstract: Type I and II diabetes adversely affect the microvasculature of several organs, although the regulatory mechanisms remain unclear. Previous studies have found that differentially expressed circRNAs associated with hyperglycemia (HG) induce endothelial dysfunction. In the… read more here.
Keywords: endothelial dysfunction; hsa circ; circ 0022742; mir 503 ... See more keywords
MiR-503 suppresses hypoxia-induced proliferation, migration and angiogenesis of endothelial progenitor cells by targeting Apelin
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2018.05.008
Abstract: HighlightsMiR‐503 suppresses hypoxia‐induced proliferation, migration and angiogenesis of endothelial progenitor cells.MiR‐503 directly targets to Apelin via its 3′‐UTR region in EPCs.Increased expression of Apelin promotes EPC growth, migration and angiogenesis under hypoxia. ABSTRACT Endothelial progenitor… read more here.
Keywords: proliferation migration; migration angiogenesis; mir 503; apelin ... See more keywords
miR-503-5p inhibits colon cancer tumorigenesis, angiogenesis, and lymphangiogenesis by directly downregulating VEGF-A
Sign Up to like & getrecommendations! Published in 2020 at "Gene Therapy"
DOI: 10.1038/s41434-020-0167-3
Abstract: MicroRNAs (miRNAs) are considered important in the pathogenesis of colon cancer. But the mechanism of their role in colon cancer is still largely unknown. Here, we aimed to explore the function of miR-503-5p in the… read more here.
Keywords: lymphangiogenesis; angiogenesis; mir 503; colon ... See more keywords
Mir-424 and Mir-503 Regulates Cobll1 Expression during the CML Progression
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.4177.4177
Abstract: Up- or down-regulation of many miRNAs plays an important role in chronic myeloid leukemia (CML), however underlying mechanisms remain to be elucidated. Here, we report miRNA-424 and miR-503 regulates Cobll1 expression during CML progression. In… read more here.
Keywords: mir 424; mir 503; mir; cobll1 ... See more keywords
Circ_0003266 sponges miR-503-5p to suppress colorectal cancer progression via regulating PDCD4 expression
Sign Up to like & getrecommendations! Published in 2021 at "BMC Cancer"
DOI: 10.1186/s12885-021-07997-0
Abstract: Background Circular RNAs (circRNAs) feature prominently in tumor progression. However, the biological function and molecular mechanism of circ_0003266 in colorectal cancer (CRC) require further investigation. Methods Circ_0003266 expression in 46 pairs CRC tissues / adjacent… read more here.
Keywords: mir 503; progression; expression; crc ... See more keywords
Repression of lncRNA PART1 attenuates ovarian cancer cell viability, migration and invasion through the miR-503-5p/FOXK1 axis
Sign Up to like & getrecommendations! Published in 2022 at "BMC Cancer"
DOI: 10.1186/s12885-021-09005-x
Abstract: Background Ovarian cancer (OC) is a female malignant tumor with a high fatality rate. Long non-coding RNAs (lncRNAs) are deeply involved in OC progression. The aim of this study is to explore the specific mechanism… read more here.
Keywords: part1; foxk1; cell viability; viability migration ... See more keywords
miR-503-5p induces doxorubicin resistance in triple-negative breast cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.1083
Abstract: 1083Background: Triple-negative breast cancer (TNBC) is an aggressive breast cancer (BC) subtype comprising approximately 15% of BC. Conventional cytotoxic chemotherapies continue to be the mainsta... read more here.
Keywords: mir 503; negative breast; breast cancer; breast ... See more keywords
Reduced microRNA-503 expression augments lung fibroblast VEGF production in chronic obstructive pulmonary disease
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0184039
Abstract: Alterations in microRNA (miRNA) expression may contribute to COPD pathogenesis. In COPD, lung fibroblast repair functions are altered in multiple ways, including extracellular mediator release. Our prior study revealed miR-503 expression is decreased in COPD… read more here.
Keywords: vegf; lung fibroblasts; mir 503; copd ... See more keywords