Targeting of MAD2L1 by miR-515-5p involves the regulation of cell cycle arrest and apoptosis of colorectal cancer cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cell biology international"
DOI: 10.1002/cbin.11774
Abstract: Although many previous studies have found that the mitotic arrest deficient 2-like 1 (MAD2L1) protein contributes to the proliferation of colorectal cancer (CRC) cells, but the upstream mechanism of MAD2L1 is still largely elusive. This… read more here.
Keywords: arrest; mad2l1; mir 515; cell ... See more keywords
Effect and mechanism of microRNA‐515‐5p in proliferation and apoptosis of trophoblast cells in preeclampsia via manipulating histone deacetylase 2
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23649
Abstract: Preeclampsia (PE) refers to a pregnancy‐specific disease that begins with the placenta. Differentially expressed microRNAs (miRs) are a feature of PE. This study tried to elicit the functional mechanism of miR‐515‐5p in trophoblast cell behaviors… read more here.
Keywords: htr svneo; proliferation apoptosis; svneo cells; mir 515 ... See more keywords
A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b10558
Abstract: A small molecule (1) with overlapping affinity for two microRNA (miRNA) precursors was used to inform design of a dimeric compound (2) selective for one of the miRNAs. In particular, 2 selectively targets the microRNA(miR)-515… read more here.
Keywords: inhibitor; breast; small molecule; mir 515 ... See more keywords
Identification of miR-515-3p and its targets, vimentin and MMP3, as a key regulatory mechanism in esophageal cancer metastasis: functional and clinical significance
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00275-8
Abstract: Metastasis is the main factor of treatment failure in cancer patients, but the underlying mechanism remains to be elucidated and effective new treatment strategies are urgently needed. This study aims to explore novel key metastasis-related… read more here.
Keywords: mechanism; metastasis; expression; escc ... See more keywords
Circular RNA circ-LARP1B contributes to cutaneous squamous cell carcinoma progression by targeting microRNA-515-5p/TPX2 microtubule nucleation factor axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2019172
Abstract: ABSTRACT Circular RNAs (circRNAs) have shown pivotal regulatory roles in tumorigenesis and progression. Our purpose was to analyze the role of circRNA La ribonucleoprotein 1B (circ-LARP1B; hsa_circ_0070934) in cutaneous squamous cell carcinoma (CSCC) progression and… read more here.
Keywords: circ; circ larp1b; tpx2; mir 515 ... See more keywords
LncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1 inhibits colon adenocarcinoma progression via the miR-515-5p/slit guidance ligand 3 axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2024396
Abstract: ABSTRACT Dysregulated long non-coding RNAs (lncRNAs) play an important role in cancer progression. However, there have been limited reports to date of the involvement of ubiquitin-binding protein domain protein 10 antisense RNA 1 (UBXN10-AS1) in… read more here.
Keywords: binding protein; ubiquitin binding; coad; ubxn10 as1 ... See more keywords
LOXL1-AS1/miR-515-5p/STAT3 positive feedback loop facilitates cell proliferation and migration in atherosclerosis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000853
Abstract: Existing research has elucidated the critical role of long noncoding RNAs (lncRNAs) in the progression of multiple human cardiovascular diseases, including atherosclerosis (AS). Nonetheless, whether lncRNA LOXL1 antisense RNA 1 (LOXL1-AS1) regulates the biological functions… read more here.
Keywords: huvecs; loxl1; mir 515; loxl1 as1 ... See more keywords
PVT1 inhibits miR-515-5p function and modulate HMGB3 to promote the growth of prostate cancer cells.
Sign Up to like & getrecommendations! Published in 2022 at "Andrology"
DOI: 10.1111/andr.13285
Abstract: AIM This study is performed to analyze the role of long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) in prostate cancer (PCa). METHODS AND MATERIALS PVT1, miR-515-5p, and high mobility group B3 (HMGB3) mRNA… read more here.
Keywords: prostate cancer; hmgb3; expression; mir 515 ... See more keywords
Silencing of circTASP1 inhibits proliferation and induces apoptosis of acute myeloid leukaemia cells through modulating miR‐515‐5p/HMGA2 axis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16765
Abstract: Acute myeloid leukaemia (AML) is a common hematopoietic disease that is harmful to the lives of children and adults. CircRNAs are aberrantly expressed in the haematologic malignancy cells. However, the expression of circTASP1 and its… read more here.
Keywords: hmga2; proliferation; myeloid leukaemia; mir 515 ... See more keywords
CircNRIP1 Modulates the miR-515-5p/IL-25 Axis to Control 5-Fu and Cisplatin Resistance in Nasopharyngeal Carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s292180
Abstract: Background The development of drug resistance leads many NPC patients to experience disease relapse following the completion of chemotherapy. It is thus essential that the mechanistic basis for such chemoresistance be clarified in an effort… read more here.
Keywords: expression; circnrip1; cisplatin resistance; mir 515 ... See more keywords