microRNA‐99a‐5p induces cellular senescence in gemcitabine‐resistant bladder cancer by targeting SMARCD1
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13192
Abstract: Patients with advanced bladder cancer are generally treated with a combination of chemotherapeutics, including gemcitabine, but the effect is limited due to acquisition of drug resistance. Thus, in this study, we investigated the mechanism of… read more here.
Keywords: cellular senescence; gemcitabine; gemcitabine resistant; bladder cancer ... See more keywords
MicroRNA‐99a‐5p suppresses breast cancer progression and cell‐cycle pathway through downregulating CDC25A
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26906
Abstract: In this study, we aimed to explore the association between miR‐99a‐5p and CDC25A in breast cancer and the regulatory mechanisms of miR‐99a‐5p on breast cancer. The expressions of messenger RNA and microRNAs in breast cancer… read more here.
Keywords: breast cancer; mir 99a; cancer; cell ... See more keywords
MiR-99a-3p downregulates TRIM21 to promote gastric cancer development
Sign Up to like & getrecommendations! Published in 2024 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-024-05005-0
Abstract: Gastric cancer (GC) stands as one of the most formidable malignancies worldwide. It is well-established that miRNAs play a crucial role in the initiation and progression of various human cancers. Among these, miR-99a-3p has been… read more here.
Keywords: progression; mir 99a; gastric cancer; 99a downregulates ... See more keywords
PTEN/AKT/mTOR pathway involvement in autophagy, mediated by miR-99a-3p and energy metabolism in ammonia-exposed chicken bursal lymphocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Poultry science"
DOI: 10.1016/j.psj.2020.11.015
Abstract: Emission of atmospheric ammonia (NH3) is an environmental challenge because of its harmful effects on humans and animals including birds. Among all organisms, NH3 is highly sensitive to birds. Autophagy plays a critical role in… read more here.
Keywords: metabolism; ammonia; mir 99a; autophagy ... See more keywords
5-HTP Promotes Milk Calcium Level via MiR-99a-3p/ATP2B1 Axis in Goat Mammary Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b07869
Abstract: 5-HTP is the primary product that L-tryptophan converted into 5-HT by rate-limiting enzyme. Our previous study found that 5-HTP could promote intracellular calcium level in goat mammary epithelial cells (GMECs). Herein, dairy goats were injected… read more here.
Keywords: mir 99a; mammary epithelial; calcium level; epithelial cells ... See more keywords
Nanoporous Anodic Alumina-Based Sensor for miR-99a-5p Detection as an Effective Early Breast Cancer Diagnostic Tool.
Sign Up to like & getrecommendations! Published in 2021 at "ACS sensors"
DOI: 10.1021/acssensors.0c02222
Abstract: Circulating microRNAs have emerged as potential diagnostic biomarkers. The deregulation of the microRNA miR-99a-5p has been previously described as an effective biomarker of early breast cancer. Herein, we present a new nanoporous anodic alumina (NAA)-based… read more here.
Keywords: early breast; mir 99a; nanoporous anodic; breast cancer ... See more keywords
Overexpression of miR-99a promoted expansion and suppressed differentiation of hematopoietic stem/progenitor cells
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-92827-7
Abstract: MicroRNAs (miRNAs) are a class of non-coding RNAs involved in a variety of pathophysiological processes. We have previously reported that the abnormally high expression of miR-99a is associated with drug resistance and poor prognosis in… read more here.
Keywords: differentiation; hematopoietic stem; hspcs; mir 99a ... See more keywords
MiRNA-99a alleviates inflammation and oxidative stress in lipopolysaccharide-stimulated PC-12 cells and rats post spinal cord injury
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2031386
Abstract: ABSTRACT Spinal cord injury (SCI) is caused by spinal fracture after the displacement of the spine or broken bone fragments protruding into the spinal canal, resulting in different degrees of injury to the spinal cord… read more here.
Keywords: expression; oxidative stress; mir 99a; sci ... See more keywords
Altered editing level of microRNAs is a potential biomarker in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Science"
DOI: 10.1111/cas.13742
Abstract: Adenosine‐to‐inosine (A‐to‐I) microRNA editing is associated with tumor phenotypes in various cancer types. Recent analyses of The Cancer Genome Atlas (TCGA) dataset have shown several microRNAs that undergo A‐to‐I editing in human cancers, some of… read more here.
Keywords: lung adenocarcinoma; editing level; level; mir 99a ... See more keywords
MicroRNA‐99a is a novel regulator of KDM6B‐mediated osteogenic differentiation of BMSCs
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13490
Abstract: Skeletal tissue originates from mesenchymal stem cells (MSCs) with differentiation potential into the osteoblast lineage regulated by essential transcriptional and post‐transcriptional mechanisms. Recently, miRNAs and histone modifications have been identified as novel key regulators of… read more here.
Keywords: differentiation bmscs; mir 99a; differentiation; osteogenic differentiation ... See more keywords
Extracellular Vesicle-Packaged miR-99a Reprograms Fibroblasts to Create an Inflammatory Niche that Drives Colorectal Cancer Metastasis.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer research"
DOI: 10.1158/0008-5472.can-25-0663
Abstract: Inflammation and epithelial-to-mesenchymal transition (EMT) are hallmarks of cancer progression. A better understanding of the mechanisms driving these processes could help uncover strategies to treat and prevent metastasis. Here, we found that extracellular vesicle (EV)-mediated… read more here.
Keywords: cancer; mir 99a; niche; crc cells ... See more keywords