LncRNA LOXL1‐AS1/miR‐let‐7a‐5p/EGFR‐related pathway regulates the doxorubicin resistance of prostate cancer DU‐145 cells
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2075
Abstract: Our study aimed to investigate the effects of lncRNA LOXL1‐AS1/miR‐let‐7a‐5p/EGFR‐axis on prostate cancer (PCa) progression. Microarray analysis was conducted to determine differentially expressed lncRNAs and mRNAs. Gene Set Enrichment analysis was implemented for verification of… read more here.
Keywords: mir let; as1; loxl1 as1; prostate cancer ... See more keywords
Can increased expression of miR-Let-7c reduce the transition potential of high-grade urothelial carcinoma?
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06825-9
Abstract: BACKGROUND Bladder cancer is the leading transitional cell carcinoma affecting men and women with high morbidity and mortality rates, justifying the need to develop new molecular target therapies using microRNAs. This study aimed to evaluate… read more here.
Keywords: mir let; high grade; urothelial carcinoma; let ... See more keywords
miR-let-7a suppresses α-Synuclein-induced microglia inflammation through targeting STAT3 in Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.140
Abstract: Microglia-mediated neuroinflammation is critical for the pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD). microRNA-let-7a (miR-let-7a) targets the signal transducer and activator of transcription-3 (STAT3) and regulates microglia function. However, less is known about whether… read more here.
Keywords: let suppresses; mir let; inflammation targeting; targeting stat3 ... See more keywords
Exosome-derived miR-let-7c promotes angiogenesis in multiple myeloma by polarizing M2 macrophages in the bone marrow microenvironment.
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia research"
DOI: 10.1016/j.leukres.2021.106566
Abstract: Angiogenesis is an integral part of the multiple myeloma (MM) microenvironment, and affects tumorigenesis, progression, invasion, and metastasis. Exosomes are essential for cell-cell communication and help in regulating the bone marrow microenvironment. Herein, we investigated… read more here.
Keywords: myeloma; mir let; let; marrow microenvironment ... See more keywords
miR-let-7d attenuates EMT by targeting HMGA2 in silica-induced pulmonary fibrosis
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DOI: 10.1039/c9ra01031a
Abstract: Silicosis is a serious occupational disease characterized by pulmonary chronic inflammation and progressive fibrosis. read more here.
Keywords: mir let; emt targeting; fibrosis; attenuates emt ... See more keywords
Analysis of miRNA Associated with Coronary Artery Calcification
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/3708547
Abstract: Cardiovascular diseases seriously endanger human physical and mental health and life safety, to investigate correlation between miR-let-7b and miR-29b and coronary artery calcification of various patients. At present, real-time fluorescence quantitative PCR (qRT-PCR) was used… read more here.
Keywords: mir 29b; mir let; calcification; artery calcification ... See more keywords
Salivary microRNA miR-let-7a-5p and miR-3928 could be used as potential diagnostic bio-markers for head and neck squamous cell carcinoma
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DOI: 10.1371/journal.pone.0221779
Abstract: Backgrounds MicroRNAs (miRNA) are a class of non-protein-coding RNAs that have significant biological and pathological functions. The importance of miRNAs as potential cancer diagnostic biomarkers is gaining attention due to their influence in the regulation… read more here.
Keywords: mir 3928; mir let; healthy controls; mir ... See more keywords
MicroLet-7b Regulates Neutrophil Function and Dampens Neutrophilic Inflammation by Suppressing the Canonical TLR4/NF-κB Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.653344
Abstract: Sepsis is a heterogeneous syndrome caused by a dysregulated host response during the process of infection. Neutrophils are involved in the development of sepsis due to their essential role in host defense. COVID-19 is a… read more here.
Keywords: tlr4; sepsis; septic mice; mir let ... See more keywords
The Long Non-Coding RNA FAM222A-AS1 Negatively Modulates MiR-Let-7f to Promote Colorectal Cancer Progression
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.764621
Abstract: Accumulating evidence indicates that lncRNAs are potential biomarkers and key regulators of tumor development and progression. The present study aimed to screen abnormal expression lncRNAs and investigate the mechanisms underlying the function in the progression… read more here.
Keywords: mir let; progression; as1; crc ... See more keywords
MiR-21 and let-7 cooperation in the regulation of lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.950043
Abstract: Background Lung cancer occurs and develops as a result of a complicated process involving numerous genes; therefore, single-gene regulation has a limited therapeutic effect. We discovered that miR-21 expression was high in lung cancer tissues… read more here.
Keywords: lung cancer; mir let; cancer; regulation ... See more keywords
MiRNAs in Systemic Sclerosis Patients with Pulmonary Arterial Hypertension: Markers and Effectors
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10030629
Abstract: Background: Pulmonary arterial hypertension (PAH) is a major cause of death in systemic sclerosis (SSc). Early detection may improve patient outcomes. Methods: We searched for circulating miRNAs that would constitute biomarkers in SSc patients with… read more here.
Keywords: mir let; ssc pah; pulmonary arterial; pah ... See more keywords