Antitumor activity of novel POLA1-HDAC11 dual inhibitors.
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DOI: 10.1016/j.ejmech.2021.113971
Abstract: Hybrid molecules targeting simultaneously DNA polymerase α (POLA1) and histone deacetylases (HDACs) were designed and synthesized to exploit a potential synergy of action. Among a library of screened molecules, MIR002 and GEM144 showed antiproliferative activity… read more here.
Keywords: activity novel; novel pola1; mir002 gem144; antitumor activity ... See more keywords