Mir34a constrains pancreatic carcinogenesis
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DOI: 10.1038/s41598-020-66561-1
Abstract: Several studies have shown that over 70 different microRNAs are aberrantly expressed in pancreatic ductal adenocarcinoma (PDAC), affecting proliferation, apoptosis, metabolism, EMT and metastasis. The most important genetic alterations driving PDAC are a constitutive active… read more here.
Keywords: pancreatic carcinogenesis; pdac; constrains pancreatic; mir34a ... See more keywords
Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1.
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DOI: 10.1053/j.gastro.2018.08.011
Abstract: BACKGROUND & AIMS Combined inactivation of the microRNA 34a gene (MIR34A, by methylation) and the TP53 gene (by mutation or deletion) is observed in 50% of colorectal tumors that progress to distant metastases. We studied mice… read more here.
Keywords: iec mice; mir34a; mice; pai1 ... See more keywords
Csf1r mediates enhancement of intestinal tumorigenesis caused by inactivation of Mir34a
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.75503
Abstract: The CSF1 receptor (CSF1R) encoding mRNA represents a direct target of miR-34a. However, the in vivo relevance of the suppression of CSF1R by miR-34a for intestinal tumor suppression mediated by the p53/miR-34a pathway has remained… read more here.
Keywords: csf1r; deletion; mir34a csf1r; mir34a ... See more keywords