Abstract 5498: SHP2 inhibition enhances antitumor effect of mirdametinib in a pediatric brain tumor model bearing CDC42SE2BRAF fusion by rewiring the proteome and phosphoproteome landscape
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DOI: 10.1158/1538-7445.am2023-5498
Abstract: Pediatric gliomas are the most common type of pediatric brain tumors representing wide range of molecularly and clinically heterogenous subtypes. The hyperactivity of mitogen-activated protein kinases (MAPK) pathway has been identified in the majority of… read more here.
Keywords: mirdametinib; combination; brain; proteome phosphoproteome ... See more keywords