LncRNA Rian reduces cardiomyocyte pyroptosis and alleviates myocardial ischemia–reperfusion injury by regulating by the miR-17-5p/CCND1 axis
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DOI: 10.1038/s41440-022-00884-6
Abstract: Myocardial ischemia–reperfusion injury (MIRI) is a pathological process characterized by cardiomyocyte death. Long noncoding RNAs (lncRNAs) have been shown to be dysregulated in the course of MIRI. Accordingly, the current study investigated the mechanism of… read more here.
Keywords: miri; lncrna rian; pyroptosis; cardiomyocyte pyroptosis ... See more keywords
Downregulation of Gldc attenuates myocardial ischemia reperfusion injury in vitro by modulating Akt and NF-κB signalings
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DOI: 10.1038/s41598-024-79445-5
Abstract: Myocardial ischemia/reperfusion injury (MIRI) is a serious clinical complication that is caused by reperfusion therapy following myocardial infarction (MI). Mitochondria-related genes (Mito-RGs) play important roles in multiple diseases. However, the role of mitochondria-related genes in… read more here.
Keywords: myocardial ischemia; ischemia reperfusion; reperfusion; gldc ... See more keywords
Spherical α-helical polypeptide-mediated E2F1 silencing against myocardial ischemia-reperfusion injury (MIRI).
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm01075e
Abstract: Apoptosis of cardiomyocytes is a critical outcome of myocardial ischemia-reperfusion injury (MIRI), which leads to the permanent impairment of cardiac function. Upregulated E2F1 is implicated in inducing cardiomyocyte apoptosis, and thus intervention of the E2F1… read more here.
Keywords: reperfusion injury; miri; myocardial ischemia; injury miri ... See more keywords
OP35 Efficacy of mirikizumab in comparison to ustekinumab in patients with moderate to severe Crohn’s disease: Results from the phase 3 VIVID 1 study
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DOI: 10.1093/ecco-jcc/jjad212.0035
Abstract: The primary objective of the VIVID-1 trial (NCT03926130) was to demonstrate efficacy and safety of mirikizumab (miri), a p19-directed anti-IL-23 antibody, compared to placebo (PBO) in patients (pts) with moderate-to-severe Crohn’s disease. Miri demonstrated statistically… read more here.
Keywords: response; crohn; miri; clinical remission ... See more keywords
P1044 Mirikizumab Pharmacokinetics and Exposure-Response in a Phase 2 Study in Patients With Moderately to Severely Active Crohn’s Disease
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjad212.1174
Abstract: Mirikizumab (miri) is a humanized anti–interleukin-23-p19 monoclonal antibody approved for the treatment of ulcerative colitis (UC) and under development for Crohn’s disease (CD). This analysis characterises miri pharmacokinetics (PK) and the relationship between miri exposure… read more here.
Keywords: miri; response; phase; crohn disease ... See more keywords
P1048 Mirikizumab administration experience from Ulcerative Colitis patients: Survey data from the LUCENT clinical program
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DOI: 10.1093/ecco-jcc/jjad212.1178
Abstract: Mirikizumab (MIRI) is an anti-IL-p19 antibody approved for moderately-to-severely active ulcerative colitis (UC). The recommended dose regimen has 2 parts: MIRI administration begins with intravenous (IV) infusion every 4 weeks (Q4W; 3 total) and is… read more here.
Keywords: satisfaction; survey; administration; miri ... See more keywords
DOP005 Long-term efficacy and safety of mirikizumab treatment for Crohn’s Disease: Results from the VIVID-2 open-label extension study
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DOI: 10.1093/ecco-jcc/jjae190.0044
Abstract: VIVID-2 (NCT04232553) is an ongoing open-label long-term extension study of efficacy and safety of mirikizumab (MIRI), a selective interleukin-23p19 inhibitor, in patients with moderately to severely active Crohn’s disease (CD). We present efficacy and safety… read more here.
Keywords: safety; endoscopic remission; miri; vivid ... See more keywords
DOP046 Effectiveness and Safety of Mirikizumab after switching from Ustekinumab in patients with moderate to severe Crohn’s disease: results from a long-term extension study
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DOI: 10.1093/ecco-jcc/jjae190.0085
Abstract: Mirikizumab (Miri), an interleukin-23p19 inhibitor, has shown strong efficacy and was well-tolerated in patients with moderately-to-severely active Crohn’s disease (CD) in the Phase 3 study VIVID-1 (NCT03926130) (1). We report one-year efficacy and safety of… read more here.
Keywords: crohn disease; safety; miri; crohn ... See more keywords
P1112 Pharmacokinetic comparability and safety between original and citrate-free mirikizumab formulations for subcutaneous injections: Results from three clinical trials in healthy participants
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DOI: 10.1093/ecco-jcc/jjae190.1286
Abstract: Mirikizumab (miri), a humanized IgG4 monoclonal antibody which selectively binds to the p19 subunit of human IL-23, is administered via subcutaneous (SC) injection. Since injection site pain (ISP) may be negatively affected by formulation buffer… read more here.
Keywords: formulation; pain; citrate free; miri ... See more keywords
mirisim: a simulator for the Mid-Infrared Instrument on JWST
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DOI: 10.1093/mnras/staa3416
Abstract: The Mid-Infrared Instrument (MIRI) on the James Webb Space Telescope (JWST), has imaging, four coronagraphs and both low and medium resolution spectroscopic modes . Being able to simulate MIRI observations will help commissioning of the… read more here.
Keywords: miri; mirisim; infrared instrument; mid infrared ... See more keywords
Observations of the planetary nebula SMP LMC 058 with the JWST MIRI medium resolution spectrometer
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DOI: 10.1093/mnras/stad1609
Abstract: During the commissioning of JWST, the Medium-Resolution Spectrometer (MRS) on the Mid-Infrared Instrument (MIRI) observed the planetary nebula SMP LMC 058 in the Large Magellanic Cloud. The MRS was designed to provide medium resolution (R… read more here.
Keywords: smp lmc; miri; medium resolution; lmc 058 ... See more keywords