miRISC Composition Determines Target Fates in Time and Space.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.10.009
Abstract: MicroRNA-mediated gene silencing can occur by either target mRNA degradation or translational repression. In this issue of Developmental Cell, Dallaire et al. (2018) show in C. elegans that tissue-specific composition of the silencing complex, miRISC, plays… read more here.
Keywords: mirisc; determines target; mirisc composition; target fates ... See more keywords
E-cadherin Interacts With Posttranslationally-Modified AGO2 to Enhance miRISC Activity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.671244
Abstract: MicroRNAs (miRNAs) are small non-coding RNAs which post-transcriptionally suppress target mRNAs expression and/or translation to modulate pathophyological processes. Expression and function of miRNAs are fine-tuned by a conserved biogenesis machinery involves two RNase-dependent processing steps… read more here.
Keywords: mirisc; mirisc activity; cadherin interacts; interacts posttranslationally ... See more keywords
Roles of the Core Components of the Mammalian miRISC in Chromatin Biology
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13030414
Abstract: The Argonaute (AGO) and the Trinucleotide Repeat Containing 6 (TNRC6) family proteins are the core components of the mammalian microRNA-induced silencing complex (miRISC), the machinery that mediates microRNA function in the cytoplasm. The cytoplasmic miRISC-mediated… read more here.
Keywords: chromatin biology; mirisc; core components; biology ... See more keywords