Biodegradable Polymers as a Noncoding miRNA Nanocarrier for Multiple Targeting Therapy of Human Hepatocellular Carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201801318
Abstract: Therapeutic strategy based on the restoration of tumor suppressor-microRNAs (miRNAs) is a promising approach for cancer therapy, but the low delivery efficiency of miRNA remains a huge hurdle due to the lack of safe and… read more here.
Keywords: hepatocellular carcinoma; peg bcpvs; mirna; mir26a mir122 ... See more keywords
Adipose‐derived exosomal MicroRNAs orchestrate gene regulation in the liver: Is this the missing link in nonalcoholic fatty liver disease?
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.29343
Abstract: It has long been known that adipose tissue has functions beyond the storage of lipids. More particularly, adipocytes secrete hormones and other molecular cues, including adipokines that actively influence metabolism at distant tissue sites. However,… read more here.
Keywords: mirna; tissue; fgf21; mice ... See more keywords
MicroRNA‐9a‐5p inhibits mucosal barrier injury in inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23131
Abstract: Our previous research found that FOXO1 aggravates the mucosal barrier injury in inflammatory bowel disease (IBD) by regulating TLR4/MD2 signaling. In this study, we further reveal the mechanism of action whereby miRNA‐9a‐5p inhibits the mucosal… read more here.
Keywords: mucosal barrier; barrier injury; disease; inflammatory ... See more keywords
Integrated mRNA‐Seq and miRNA‐Seq analysis of PLCγ2‐overexpressing hepatocarcinoma cells and identification of the associated miRNA‐mRNA network
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29294
Abstract: Our previous study has discovered the positive effect of phospholipase Cγ 2 (PLCγ2) on the growth of hepatocarcinoma cells; however, the underlying mechanism is far from being understood. For this reason, this study attempts to… read more here.
Keywords: seq; mirna; hepatocarcinoma cells; mirna mrna ... See more keywords
Roles of microRNAs in preeclampsia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27291
Abstract: Preeclampsia (PE) is a complex disorder that is characterized by hypertension and proteinuria after the 20th week of pregnancy, and it causes most neonatal morbidity and perinatal mortality. Most studies suggest that placental dysfunction is… read more here.
Keywords: mirna; micrornas preeclampsia; physiology; preeclampsia ... See more keywords
Platelet removal from human blood plasma improves detection of extracellular vesicle‐associated miRNA
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12302
Abstract: Abstract Human blood plasma prepared by centrifugation contains not only extracellular vesicles (EVs) but also platelets and erythrocyte ghosts (ery‐ghosts). Here we studied whether analysis of miRNA associated with plasma EVs (EV‐miRNA) is affected by… read more here.
Keywords: blood plasma; ery ghosts; human blood; mirna ... See more keywords
Dietary flavonoid narirutin as a prospective antagonist of oncogenic pri/pre‐microRNAs
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7367
Abstract: MicroRNAs (miRNAs) are involved in cancer progression via translational degradation in a sequence‐specific manner of the 3′‐untranslated region (3′UTR) of messenger RNA (mRNA). The involvement of miRNA in the biological progression of various cancer types… read more here.
Keywords: pri mir; kcal mol; pri; pre ... See more keywords
microRNA‐binding proteins: specificity and function
Sign Up to like & getrecommendations! Published in 2017 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1414
Abstract: microRNA (miRNA) and RNA‐binding proteins (RBPs) have been studied widely in post‐transcriptional gene regulation. Previous work has focused on defining how miRNA and RBPs modulate target mRNA decay and translation as well as investigating how… read more here.
Keywords: mirna; binding proteins; specificity function; rbps ... See more keywords
Post‐transcriptional regulation of polycistronic microRNAs
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1749
Abstract: An important proportion of microRNA (miRNA) genes tend to lie close to each other within animal genomes. Such genomic organization is generally referred to as miRNA clusters. Even though many miRNA clusters have been greatly… read more here.
Keywords: regulation polycistronic; mirna clusters; transcriptional regulation; post transcriptional ... See more keywords
Innovative approaches in transforming microRNAs into therapeutic tools
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1768
Abstract: MicroRNA (miRNA) is regarded as a prominent genetic regulator, as it can fine‐tune an entire biological pathway by targeting multiple target genes. This characteristic makes miRNAs promising therapeutic tools to reinstate cell functions that are… read more here.
Keywords: innovative approaches; therapeutic tools; micrornas therapeutic; approaches transforming ... See more keywords
Quantum Language of MicroRNA: Application for New Cancer Therapeutic Targets.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7601-0_12
Abstract: MicroRNA (miRNA) is the noncoding gene: therefore, the miRNA gene inheritably controls protein gene expression through transcriptional and post-transcriptional levels. Aberrant expression of miRNA genes causes various human diseases, especially cancers. Although cancer is a… read more here.
Keywords: mirna; mirna target; cancer; gene ... See more keywords