Development of a miRNA‐based classifier for detection of colorectal cancer molecular subtypes
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13210
Abstract: Previously, colorectal cancer (CRC) has been classified into four distinct molecular subtypes based on transcriptome data. These consensus molecular subtypes (CMSs) have implications for our understanding of tumor heterogeneity and the prognosis of patients. So… read more here.
Keywords: molecular subtypes; cms miracl; mirna based; detection ... See more keywords
Engineering Bioactive M2 Macrophage-Polarized, Anti-inflammatory, miRNA-Based Liposomes for Functional Muscle Repair: From Exosomal Mechanisms to Biomaterials.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202201957
Abstract: Severe inflammation and myogenic differentiation disorder are the major obstacles to skeletal muscle healing after injury. MicroRNAs (miRNAs) play an important role as regulatory molecules during the process of muscle healing, but the detailed mechanism… read more here.
Keywords: inflammatory mirna; mir 224; muscle; anti inflammatory ... See more keywords
MiRNA-based drugs: challenges and delivery strategies
Sign Up to like & getrecommendations! Published in 2025 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-025-13620-0
Abstract: The miRNA-based therapeutics held great promise for the treatment of diseases associated with aberrant gene expression. However, the development of miRNA-based drugs still faces many obstacles, including stability, targetability, tissue penetration, and induction of immune… read more here.
Keywords: based drugs; mirna based; delivery; delivery systems ... See more keywords
MicroRNA signatures in osteosarcoma: diagnostic insights and therapeutic prospects
Sign Up to like & getrecommendations! Published in 2024 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-024-05135-5
Abstract: Osteosarcoma (OSa) is the most prevalent primary malignant bone tumor in children and adolescents, characterized by complex genetic and epigenetic alterations. Traditional treatments face significant challenges due to high rates of drug resistance and lack… read more here.
Keywords: mirna based; diagnostic insights; osteosarcoma diagnostic; insights therapeutic ... See more keywords
MiRNA expression patterns are associated with tumor mutational burden in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "OncoImmunology"
DOI: 10.1080/2162402x.2019.1629260
Abstract: ABSTRACT Background: Tumor mutational burden (TMB) has emerged as an independent biomarker to predict patient responses to treatment with immune checkpoint inhibitors (ICIs) for lung adenocarcinoma (LUAD). MicroRNAs (miRNAs) have a crucial role in the… read more here.
Keywords: expression; mirna based; signature classifier; tumor mutational ... See more keywords
MiRNA-Based Therapies for the Treatment of Inflammatory Bowel Disease: What Are We Still Missing?
Sign Up to like & getrecommendations! Published in 2022 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izac122
Abstract: Micro-RNAs (miRNAs) are noncoding RNAs usually 24-30 nucleotides long that play a central role in epigenetic mechanisms of inflammatory diseases and cancers. Recently, several studies have assessed the involvement of miRNAs in the pathogenesis of… read more here.
Keywords: bowel; inflammatory bowel; mirna based; bowel disease ... See more keywords
MiRNA-based model for predicting the TMB level in colon adenocarcinoma based on a LASSO logistic regression method
Sign Up to like & getrecommendations! Published in 2021 at "Medicine"
DOI: 10.1097/md.0000000000026068
Abstract: Abstract Some patients with advanced colon adenocarcinoma (COAD) are not sensitive to radiotherapy and chemotherapy, and as such, immunotherapy has become the most popular option for these patients. However, different patients respond differently to immunotherapy.… read more here.
Keywords: mirna based; coad; model; based model ... See more keywords
Cell Dissociation Enzymes Affect Annexin V/Flow-Cytometric Apoptotic Assay Outcomes After miRNA-based Transient Transfection
Sign Up to like & getrecommendations! Published in 2022 at "AntiCancer Research"
DOI: 10.21873/anticanres.15763
Abstract: Background/Aim: miRNA functional analysis involves transfection with miRNA-based oligos to identify gain-of or loss-of function cellular phenotypes. Apoptosis is a common phenotypic endpoint for miRNA functional analysis. We report that four common cell dissociation enzymes,… read more here.
Keywords: cell; dissociation enzymes; annexin; cell dissociation ... See more keywords
Fission Impossible: Stabilized miRNA-Based Analogs in Neurodegenerative Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.875957
Abstract: of exhibiting a specific down-regulation of brain-enriched miRNA in miRNA is a major in the most CA1 in findings read more here.
Keywords: analogs neurodegenerative; stabilized mirna; fission impossible; based analogs ... See more keywords
MiRNA-Based Therapies for Lung Cancer: Opportunities and Challenges?
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13060877
Abstract: Lung cancer is a commonly diagnosed cancer and the leading cause of cancer-related deaths, posing a serious health risk. Despite new advances in immune checkpoint and targeted therapies in recent years, the prognosis for lung… read more here.
Keywords: lung cancer; based therapies; therapies lung; mirna based ... See more keywords
Potential of miRNA-Based Nanotherapeutics for Uveal Melanoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13205192
Abstract: Simple Summary Human uveal melanoma (UM) is the most common primary intraocular tumor with high metastatic risk in adults. Currently, no effective treatment is available for metastatic UM; therefore, new therapeutic approaches are needed to… read more here.
Keywords: delivery systems; uveal melanoma; mirna based; nanotechnology ... See more keywords