Systemic CLIP-seq analysis and game theory approach to model microRNA mode of binding
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab198
Abstract: Abstract microRNAs (miRNAs) associate with Ago proteins to post-transcriptionally silence gene expression by targeting mRNAs. To characterize the modes of miRNA-binding, we developed a novel computational framework, called optiCLIP, which considers the reproducibility of the… read more here.
Keywords: clip seq; mode binding; mirna binding; binding sites ... See more keywords
A Viral Suppressor Modulates the Plant Immune Response Early in Infection by Regulating MicroRNA Activity
Sign Up to like & getrecommendations! Published in 2018 at "mBio"
DOI: 10.1128/mbio.00419-18
Abstract: ABSTRACT Many viral suppressors (VSRs) counteract antiviral RNA silencing, a central component of the plant’s immune response by sequestration of virus-derived antiviral small interfering RNAs (siRNAs). Here, we addressed how VSRs affect the activities of… read more here.
Keywords: plant immune; response; plant; infection ... See more keywords
Impact of miRNA-binding site polymorphisms in STAT3 gene on occurrence and clinical characteristics of systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2022 at "Lupus"
DOI: 10.1177/09612033221076739
Abstract: Background Signal transducer and activator of transcription 3 (STAT3) is a major regulator of immune response and chronic inflammatory conditions acting through regulation of B cells, T-helper 17 (Th17) cells, and IL-17 production. Previous studies… read more here.
Keywords: mirna binding; polymorphisms stat3; disease; binding site ... See more keywords
Impact of Natural Occurring ERAP1 Single Nucleotide Polymorphisms within miRNA-Binding Sites on HCMV Infection
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21165861
Abstract: Human cytomegalovirus (HCMV) is a β-herpesvirus that causes serious problems in people with a compromised immune system, whereas it coexists asymptomatically within the host with a healthy immune system. Like other viruses, HCMV has adopted… read more here.
Keywords: within mirna; nucleotide polymorphisms; single nucleotide; mirna binding ... See more keywords
Two prostate cancer‑associated polymorphisms in the 3'UTR of IGF1R influences prostate cancer susceptibility by affecting miRNA binding.
Sign Up to like & getrecommendations! Published in 2019 at "Oncology reports"
DOI: 10.3892/or.2018.6810
Abstract: Prostate cancer (PCa) is a common malignant cancer in men worldwide. Numerous genetic variations have been associated with PCa, but their biological function remains unclear. Single nucleotide polymorphisms (SNPs) inside 3' untranslated region (UTR) affect gene… read more here.
Keywords: cancer susceptibility; prostate cancer; mirna binding; two prostate ... See more keywords
Functional variants of TIM-3/HAVCR2 3′UTR in lymphoblastoid cell lines
Sign Up to like & getrecommendations! Published in 2018 at "Future Science OA"
DOI: 10.4155/fsoa-2017-0121
Abstract: Aim: Variants of TIM-3/HAVCR2 3′UTR miRNA binding sites are significantly associated with cancer; however, roles in post-transcriptional regulation have not been elucidated. Methods: The regulatory and coding region single nucleotide polymorphisms (SNPs) of TIM-3/HAVCR2 were… read more here.
Keywords: havcr2; variants tim; havcr2 utr; mirna binding ... See more keywords
Prediction of clusters of miRNA binding sites in mRNA candidate genes of breast cancer subtypes
Sign Up to like & getrecommendations! Published in 2019 at "PeerJ"
DOI: 10.7717/peerj.8049
Abstract: The development of breast cancer (BC) subtypes is controlled by distinct sets of candidate genes, and the expression of these genes is regulated by the binding of their mRNAs with miRNAs. Predicting miRNA associations and… read more here.
Keywords: cancer subtypes; binding sites; breast cancer; candidate genes ... See more keywords