MiRNA Biogenesis and Regulation of Diseases: An Overview.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6524-3_1
Abstract: MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and translational repression by binding to target mRNAs. Since it was discovered in 1993, miRNA are found in all eukaryotic cells conserved across… read more here.
Keywords: biogenesis regulation; mirna biogenesis; biology; regulation diseases ... See more keywords
HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular plant"
DOI: 10.1016/j.molp.2020.12.019
Abstract: Post-transcriptional gene silencing mediated by microRNAs (miRNAs) modulates numerous developmental and stress response pathways. For the last two decades, HASTY (HST), the ortholog of human Exportin-5, has been considered as a candidate protein that exports… read more here.
Keywords: mirna biogenesis; modulates mirna; hasty modulates; transcription processing ... See more keywords
Amyotrophic Lateral Sclerosis-Associated Mutants of SOD1 Modulate miRNA Biogenesis through Aberrant Interactions with Exportin 5.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00591
Abstract: Mutations in the SOD1 (superoxide dismutase 1) gene are associated with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. By employing ascorbate peroxidase-based proximity labeling, coupled with LC-MS/MS analysis, we uncovered 43 and 24 proteins… read more here.
Keywords: associated mutants; mutants sod1; lateral sclerosis; mirna biogenesis ... See more keywords
Regulating miRNA-21 Biogenesis By Bifunctional Small Molecules.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b00610
Abstract: We report a new strategy to regulate microRNAs (miRNAs) biogenesis by using bifunctional small molecules that consist of a pre-miRNA binding unit connected by a linker to a Dicer inhibiting unit. In this effort, fluorescence… read more here.
Keywords: bifunctional small; biogenesis bifunctional; small molecules; mirna biogenesis ... See more keywords
Recapitulating miRNA biogenesis in cells
Sign Up to like & getrecommendations! Published in 2022 at "Nature Methods"
DOI: 10.1038/s41592-021-01385-z
Abstract: MapToCleave enables the large-scale study of miRNA precursor processing in living cells. read more here.
Keywords: recapitulating mirna; biogenesis cells; mirna biogenesis;
HYL1-CLEAVAGE SUBTILASE 1 (HCS1) suppresses miRNA biogenesis in response to light-to-dark transition
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116757119
Abstract: Significance HYPONASTIC LEAVES 1 (HYL1)-CLEAVAGE SUBTILASE 1 (HCS1) is a novel negative regulator of microRNA (miRNA) biogenesis that degrades HYL1 in the cytoplasm. Furthermore, cytoplasm CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) E3 ligase inhibit HCS1-mediated HYL1 degradation.… read more here.
Keywords: cop1; hyl1; mirna biogenesis; hcs1 ... See more keywords
Recent advances in the regulation of plant miRNA biogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "RNA biology"
DOI: 10.1080/15476286.2021.1899491
Abstract: MicroRNAs (miRNAs) are essential non-coding riboregulators of gene expression in plants and animals. In plants, miRNAs guide their effector protein named ARGONAUTE (AGO) to find target RNAs for gene silencing through target RNA cleavage or… read more here.
Keywords: mirna; regulation plant; advances regulation; mirna biogenesis ... See more keywords
Keeping up with the miRNAs: current paradigms of the biogenesis pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of experimental botany"
DOI: 10.1093/jxb/erac322
Abstract: For many years we have studied the processes involved in producing microRNAs (miRNAs) in plants and the numerous differences with the metazoan counterpart. A well-defined catalytic process, mostly carried out by the RNase III enzyme… read more here.
Keywords: paradigms biogenesis; biogenesis; mirna biogenesis; keeping mirnas ... See more keywords
Spliceosome disassembly factors ILP1 and NTR1 promote miRNA biogenesis in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz526
Abstract: Abstract The intron-lariat spliceosome (ILS) complex is highly conserved among eukaryotes, and its disassembly marks the end of a canonical splicing cycle. In this study, we show that two conserved disassembly factors of the ILS… read more here.
Keywords: mirna; arabidopsis thaliana; ilp1 ntr1; disassembly factors ... See more keywords
Regulation of miRNA Biogenesis and Histone Modification by K63-Polyubiquitinated DDX17 Controls Cancer Stem-like Features.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-2376
Abstract: Markers of cancer stemness predispose patients to tumor aggressiveness, drug and immunotherapy resistance, relapse, and metastasis. DDX17 is a cofactor of the Drosha-DGCR8 complex in miRNA biogenesis and transcriptional coactivator and has been associated with… read more here.
Keywords: stem like; ddx17; cancer; mirna biogenesis ... See more keywords
Complexity in regulating microRNA biogenesis in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Biology and Medicine"
DOI: 10.1177/1535370220907314
Abstract: The discovery of microRNA (miRNA) significantly extends our knowledge on gene regulation and noncoding gene functions. MiRNAs are important post-transcriptional regulators involve in a wide range of biological functions and diseases, including cancer. MiRNAs are… read more here.
Keywords: mirna biogenesis; regulating microrna; cancer; complexity regulating ... See more keywords