Postâtranscriptional regulation of polycistronic microRNAs
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1749
Abstract: An important proportion of microRNA (miRNA) genes tend to lie close to each other within animal genomes. Such genomic organization is generally referred to as miRNA clusters. Even though many miRNA clusters have been greatly… read more here.
Keywords: regulation polycistronic; mirna clusters; transcriptional regulation; post transcriptional ... See more keywords
Mechanosensitive pathways are regulated by mechanosensitive miRNA clusters in endothelial cells
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical Reviews"
DOI: 10.1007/s12551-021-00839-0
Abstract: Shear stress is known to affect many processes in (patho-) physiology through a complex, multi-molecular mechanism, termed mechanotransduction. The sheer complexity of the process has raised questions how mechanotransduction is regulated. Here, we comprehensively evaluate… read more here.
Keywords: pathways regulated; mirna clusters; mechanotransduction; regulated mechanosensitive ... See more keywords
Defining the rhesus macaque placental miRNAome: Conservation of expression of placental miRNA clusters between the macaque and human.
Sign Up to like & getrecommendations! Published in 2018 at "Placenta"
DOI: 10.1016/j.placenta.2018.04.003
Abstract: OBJECTIVE Expression of microRNAs (miRNAs) in the human placenta is dynamic across gestation, with expression of miRNAs belonging to the C14MC, C19MC and miR-371-3 clusters. Specifically, miRNAs within the C19MC cluster are exclusively expressed in… read more here.
Keywords: mirna clusters; macaque human; clusters macaque; placenta ... See more keywords
CRISPRi for specific inhibition of miRNA clusters and miRNAs with high sequence homology
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-10336-3
Abstract: miRNAs form a class of noncoding RNAs, involved in post-transcriptional regulation of gene expression, broadly studied for their involvement in physiological and pathological context. Inhibition of mature miRNA transcripts, commonly used in miRNA loss-of-function experiments,… read more here.
Keywords: mirna clusters; high sequence; inhibition; mirnas high ... See more keywords