Hypermethylated Genes of MicroRNA in Ovarian Carcinoma: Metastasis Prediction Marker Systems
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-019-04465-5
Abstract: We identified a group of miRNA genes whose methylation is associated with ovarian cancer metastasis. Based on these data, new markers and the systems of markers predicting tumor dissemination were selected. Using methylation-specific PCR and… read more here.
Keywords: methylation; mir; mirna genes; metastasis ... See more keywords
Polymorphisms in miRNA genes and their involvement in autoimmune diseases susceptibility
Sign Up to like & getrecommendations! Published in 2017 at "Immunologic Research"
DOI: 10.1007/s12026-017-8937-8
Abstract: MicroRNAs (miRNAs) are small non-coding RNA molecules that negatively regulate the expression of multiple protein-encoding genes at the post-transcriptional level. MicroRNAs are involved in different pathways, such as cellular proliferation and differentiation, signal transduction and… read more here.
Keywords: polymorphisms mirna; involvement autoimmune; autoimmune diseases; mirna genes ... See more keywords
Novel miRNA genes deregulated by aberrant methylation in ovarian carcinoma are involved in metastasis.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.04.005
Abstract: Methylation of promoter CpG islands may suppress the function of miRNAs by inhibiting their expression. Our work analyzes the role of promoter methylation in altering the expression of 12 miRNAs associated with epithelial ovarian cancer… read more here.
Keywords: methylation; aberrant methylation; mirna genes; metastasis ... See more keywords
Evolution after Whole-Genome Duplication: Teleost MicroRNAs
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msab105
Abstract: Abstract MicroRNAs (miRNAs) are important gene expression regulators implicated in many biological processes, but we lack a global understanding of how miRNA genes evolve and contribute to developmental canalization and phenotypic diversification. Whole-genome duplication events… read more here.
Keywords: evolution whole; mirna genes; whole genome; genome duplication ... See more keywords
Comprehensive survey and evolutionary analysis of genome-wide miRNA genes from ten diploid Oryza species
Sign Up to like & getrecommendations! Published in 2017 at "BMC Genomics"
DOI: 10.1186/s12864-017-4089-4
Abstract: BackgroundMicroRNAs (miRNAs) are non-coding RNAs that play versatile roles in post-transcriptional gene regulation. Although much is known about their biogenesis, and gene regulation very little is known about their evolutionary relation among the closely related… read more here.
Keywords: across oryza; analysis; oryza species; mirna genes ... See more keywords
Imprinted MicroRNA Gene Clusters in the Evolution, Development, and Functions of Mammalian Placenta
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00706
Abstract: In mammals, the expression of a subset of microRNA (miRNA) genes is governed by genomic imprinting, an epigenetic mechanism that confers monoallelic expression in a parent-of-origin manner. Three evolutionarily distinct genomic intervals contain the vast… read more here.
Keywords: imprinted microrna; mirna genes; placenta; microrna gene ... See more keywords
Genetic Polymorphisms in microRNA Genes Targeting PI3K/Akt Signal Pathway Modulate Cervical Cancer Susceptibility in a Chinese Population
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.856505
Abstract: Polymorphisms in microRNA (miRNA) genes could influence the expression of miRNAs that regulate the PI3K/Akt signalling pathway and play crucial roles in cancer susceptibility. To investigate the association of single nucleotide polymorphisms (SNPs) in miRNA… read more here.
Keywords: pi3k akt; mirna genes; snps; polymorphisms microrna ... See more keywords
Aberrant Methylation of 20 miRNA Genes Specifically Involved in Various Steps of Ovarian Carcinoma Spread: From Primary Tumors to Peritoneal Macroscopic Metastases
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031300
Abstract: Our work aimed to differentiate 20 aberrantly methylated miRNA genes that participate at different stages of development and metastasis of ovarian carcinoma (OvCa) using methylation-specific qPCR in a representative set of clinical samples: 102 primary… read more here.
Keywords: ovarian carcinoma; peritoneal macroscopic; methylation; primary tumors ... See more keywords