Robust Filtering and Noise Suppression in Intragenic miRNA-Mediated Host Regulation
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DOI: 10.1016/j.isci.2020.101595
Abstract: Summary MicroRNAs (miRNAs) are short non-coding RNA molecules that regulate gene expression post-transcriptionally by binding to target messenger RNAs (mRNAs). Many human miRNAs are intragenic, located within introns of protein-coding sequence (host). Intriguingly, a percentage… read more here.
Keywords: mirna; host; intragenic mirna; mirna mediated ... See more keywords
Identification of browning-related microRNAs and their targets reveals complex miRNA-mediated browning regulatory networks in Luffa cylindrica
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33896-9
Abstract: As a non-coding and endogenous small RNA, MicroRNA (miRNA) takes a vital regulatory role in plant growth and development. Long-term storage and processing of many fruits and vegetables, including Luffa, are subject to influences from… read more here.
Keywords: mirna mediated; mirna; identification browning; browning related ... See more keywords
Comparison of effects of tobacco cigarettes, electronic nicotine delivery systems and tobacco heating products on miRNA-mediated gene expression. A systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2022.2089610
Abstract: Abstract Objectives This work attempts to summarize current knowledge on the effects of cigarettes, electronic nicotine delivery systems and tobacco heating products on miRNA-mediated gene expression regulation and on their possible impact on smoking-related respiratory… read more here.
Keywords: mirna mediated; expression; mediated gene; tobacco heating ... See more keywords
Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw792
Abstract: Our current knowledge about the mechanisms of miRNA silencing is restricted to few lineages such as vertebrates, arthropods, nematodes and land plants. miRNA-mediated silencing in bilaterian animals is dependent on the proteins of the GW182… read more here.
Keywords: mediated silencing; conservation mirna; 600 million; mirna mediated ... See more keywords
Computational Identification of RNA-Seq Based miRNA-Mediated Prognostic Modules in Cancer
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Journal of Biomedical and Health Informatics"
DOI: 10.1109/jbhi.2019.2911528
Abstract: Systematic identification of miRNA prognostic signature can help decipher the effects of biomarkers in cancer treatment. A number of previous studies have only characterized a single miRNA as a promising prognostic biomarker. There is currently… read more here.
Keywords: mirna; cancer; mediated prognostic; mirna mediated ... See more keywords
Brassinosteroids inhibit miRNA-mediated translational repression by decreasing AGO1 on the endoplasmic reticulum.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13139
Abstract: Translational repression is a conserved mechanism in miRNA-guided gene silencing. In plants, ARGONAUTE1 (AGO1), the miRNA effector, localizes in the cytoplasm for mRNA cleavage and at the endoplasmic reticulum (ER) for translational repression of target… read more here.
Keywords: endoplasmic reticulum; inhibit mirna; translational repression; repression ... See more keywords
miRNAs in SARS-CoV 2: A Spoke in the Wheel of Pathogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Current pharmaceutical design"
DOI: 10.2174/1381612826999201001200529
Abstract: INTRODUCTION The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an increased mortality rate across the globe. However, the underlying mechanism of SARS-CoV-2 altering human immune response is still elusive.… read more here.
Keywords: mirnas sars; mirna; pathogenesis; sars cov ... See more keywords
MiRNA-Mediated Subpathway Identification and Network Module Analysis to Reveal Prognostic Markers in Human Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.606940
Abstract: Background Pancreatic cancer (PC) remains one of the most lethal cancers. In contrast to the steady increase in survival for most cancers, the 5-year survival remains low for PC patients. Methods We describe a new… read more here.
Keywords: network; mirna; analysis; pancreatic cancer ... See more keywords
Profiling of MicroRNAs and Their Targets in Roots and Shoots Reveals a Potential MiRNA-Mediated Interaction Network in Response to Phosphate Deficiency in the Forestry Tree Betula luminifera
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.552454
Abstract: Inorganic phosphate (Pi) is often lacking in natural and agro-climatic environments, which impedes the growth of economically important woody species. Plants have developed strategies to cope with low Pi (LP) availability. MicroRNAs (miRNAs) play important… read more here.
Keywords: mirna mediated; forestry; betula luminifera; roots shoots ... See more keywords
miRNA Mediated Noise Making of 3′UTR Mutations in Cancer
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DOI: 10.3390/genes9110545
Abstract: Somatic mutations in 3′-untranslated regions (3′UTR) do not alter amino acids and are considered to be silent in cancers. We found that such mutations can promote tumor progression by altering microRNA (miRNA) targeting efficiency and… read more here.
Keywords: mirna; utr mutations; somatic mutations; cancer ... See more keywords
miRNA-Mediated Interactions in and between Plants and Insects
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19103239
Abstract: Our understanding of microRNA (miRNA) regulation of gene expression and protein translation, as a critical area of cellular regulation, has blossomed in the last two decades. Recently, it has become apparent that in plant-insect interactions,… read more here.
Keywords: insects; interactions plants; plants insects; mediated interactions ... See more keywords