Nanoparticle Delivery of miRNA-21 Mimic to Cardiac Macrophages Improves Myocardial Remodeling after Myocardial Infarction.
Sign Up to like & getrecommendations! Published in 2018 at "Nano letters"
DOI: 10.1021/acs.nanolett.8b02578
Abstract: MicroRNA-based therapy that targets cardiac macrophages holds great potential for treatment of myocardial infarction (MI). Here, we explored whether boosting the miRNA-21 transcript level in macrophage-enriched areas of the infarcted heart could switch their phenotype… read more here.
Keywords: cardiac macrophages; mirna mimic; myocardial infarction; nanoparticle delivery ... See more keywords
A novel miRNA mimic attenuates organ injury after hepatic ischemia/reperfusion
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000003877
Abstract: miRNA 130b-3p acts as an inhibitor of eCIRP, a newly discovered DAMP in shock and sepsis. We modified this miRNA for stability. Herein we show that the novel miRNA mimic is protective in hepatic I/R… read more here.
Keywords: inflammation; mirna mimic; ome mir130; reperfusion ... See more keywords