Caspase-mediated cleavage of miRNA processing proteins Drosha, DGCR8, Dicer, and TRBP2 in heat-shocked cells and its inhibition by HSP70 overexpression
Sign Up to like & getrecommendations! Published in 2021 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-021-01242-0
Abstract: Cells respond to stress through adaptive mechanisms that limit cellular damage and prevent cell death. MicroRNAs act as regulators of stress responses and stress can impact the functioning of miRNA biogenesis pathways. We were interested… read more here.
Keywords: mirna processing; trbp2; cleavage; overexpression ... See more keywords
Phase separation of SERRATE drives dicing body assembly and promotes miRNA processing in Arabidopsis
Sign Up to like & getrecommendations! Published in 2020 at "Nature Cell Biology"
DOI: 10.1038/s41556-020-00606-5
Abstract: MicroRNA (miRNA) production entails the step-wise processing of primary miRNAs (pri-miRNAs) into precursor miRNAs (pre-miRNAs) and miRNA/* duplexes by Dicing complexes containing DCL1, HYL1 and SE, which are localized in nuclear dicing bodies (D-bodies) 1… read more here.
Keywords: phase separation; mirna processing; separation;
Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemical Biology"
DOI: 10.1038/s41589-019-0420-5
Abstract: Pseudouridine synthases (PUSs) are responsible for installation of pseudouridine (Ψ) modification in RNA. However, the activity and function of the PUS enzymes remain largely unexplored. Here we focus on human PUS10 and find that it… read more here.
Keywords: trna pseudouridylation; human pus10; mirna; mirna processing ... See more keywords
PUMILIO competes with AUF1 to control DICER1 RNA levels and miRNA processing
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac499
Abstract: Abstract DICER1 syndrome is a cancer pre-disposition disorder caused by mutations that disrupt the function of DICER1 in miRNA processing. Studying the molecular, cellular and oncogenic effects of these mutations can reveal novel mechanisms that… read more here.
Keywords: dicer1; mirna processing; control; rna ... See more keywords
DICER1 somatic mutations strongly impair miRNA processing even in benign thyroid lesions
Sign Up to like & getrecommendations! Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.26639
Abstract: The alteration of miRNA processing is a driver event in several tumors including thyroid cancer. In particular, somatic DICER1 mutations, reported in follicular-patterned lesions, are shared by benign as well as malignant tumors. In the… read more here.
Keywords: somatic mutations; dicer1 mutant; mirna processing; dicer1 somatic ... See more keywords
miRNA processing gene polymorphisms, blood DNA methylation age and long-term ambient PM2.5 exposure in elderly men.
Sign Up to like & getrecommendations! Published in 2017 at "Epigenomics"
DOI: 10.2217/epi-2017-0094
Abstract: AIM We tested whether genetic variation in miRNA processing genes modified the association of PM2.5 with DNA methylation (DNAm) age. PATIENTS & METHODS We conducted a repeated measures study based on 552 participants from the… read more here.
Keywords: pm2; age; mirna processing; dnam age ... See more keywords
Association of Polymorphisms in miRNA Processing Genes With Type 2 Diabetes Mellitus and Its Vascular Complications in a Southern Chinese Population
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2019.00461
Abstract: Objective: To evaluate the potential association between the genetic variants in miRNA processing genes (RAN, XPO5, DICER1, and TARBP2) and susceptibility to type 2 diabetes mellitus (T2DM) and its vascular complications, as well as to… read more here.
Keywords: dicer1; processing genes; mirna processing; type diabetes ... See more keywords