Quantum Language of MicroRNA: Application for New Cancer Therapeutic Targets.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7601-0_12
Abstract: MicroRNA (miRNA) is the noncoding gene: therefore, the miRNA gene inheritably controls protein gene expression through transcriptional and post-transcriptional levels. Aberrant expression of miRNA genes causes various human diseases, especially cancers. Although cancer is a… read more here.
Keywords: mirna; mirna target; cancer; gene ... See more keywords
A combinatorial in silico approach for microRNA-target identification: Order out of chaos.
Sign Up to like & getrecommendations! Published in 2021 at "Biochimie"
DOI: 10.1016/j.biochi.2021.05.004
Abstract: Contemporary computational microRNA(miRNA)-target prediction tools have been playing a vital role in pursuing putative targets for a solitary miRNA or a group of miRNAs. These tools utilise a set of probabilistic algorithms, machine learning techniques… read more here.
Keywords: target identification; mirna target; microrna; target ... See more keywords
OR19 MIRNA mediated post transcriptional regulation of HLA transcripts
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.025
Abstract: Aim MicroRNAs (miRNAs) regulate the post-transcriptional expression of targeted mRNA transcripts, however little is known about the influence of HLA polymorphisms on altered miRNA target specificity & allele specific post-transcriptional regulation. We utilize a custom… read more here.
Keywords: post transcriptional; target; hla; mirna target ... See more keywords
Improving prediction accuracy using decision-tree-based meta-strategy and multi-threshold sequential-voting exemplified by miRNA target prediction.
Sign Up to like & getrecommendations! Published in 2017 at "Genomics"
DOI: 10.1016/j.ygeno.2017.04.003
Abstract: Lots of computational predictors have been developed for fast and large-scale analysis of biological data. However, many of them were developed long time ago when training datasets or sets of input features were rather small.… read more here.
Keywords: mirna target; prediction accuracy; prediction; decision tree ... See more keywords
MicroRNA-guided prioritization of genome-wide association signals reveals the importance of microRNA-target gene networks for complex traits in cattle
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27729-y
Abstract: MicroRNAs (miRNA) are key modulators of gene expression and so act as putative fine-tuners of complex phenotypes. Here, we hypothesized that causal variants of complex traits are enriched in miRNAs and miRNA-target networks. First, we… read more here.
Keywords: target; association; mirna target; complex traits ... See more keywords
Regulation of human UDP-glycosyltransferase (UGT) genes by miRNAs
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism Reviews"
DOI: 10.1080/03602532.2022.2048846
Abstract: Abstract The human UGT gene superfamily is divided into four subfamilies (UGT1, UGT2, UGT3 and UGT8) that encodes 22 functional enzymes. UGTs are critical for the metabolism and clearance of numerous endogenous and exogenous compounds,… read more here.
Keywords: mirna target; ugt genes; regulation; target sites ... See more keywords
Diagnostics and Therapeutic Potential of miR-205 and miR-34a in Ovarian Cancer Management: A miRNA-Target-Based Analysis.
Sign Up to like & getrecommendations! Published in 2023 at "DNA and cell biology"
DOI: 10.1089/dna.2022.0487
Abstract: Epithelial ovarian cancer (EOC) treatment strategies mainly focused on surgery combined with chemotherapy. Recent targeted therapy techniques emerge as milestone and could be used for management of ovarian cancer (OC) progression with more efficacy. The… read more here.
Keywords: mirna target; target; management; analysis ... See more keywords
Prediction of human miRNA target genes using computationally reconstructed ancestral mammalian sequences
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw1085
Abstract: MicroRNAs (miRNA) are short single-stranded RNA molecules derived from hairpin-forming precursors that play a crucial role as post-transcriptional regulators in eukaryotes and viruses. In the past years, many microRNA target genes (MTGs) have been identified… read more here.
Keywords: target genes; target; mirna target; prediction human ... See more keywords
MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis
Sign Up to like & getrecommendations! Published in 2019 at "BMC Bioinformatics"
DOI: 10.1186/s12859-019-3105-x
Abstract: AbstractBackgroundmiRNAs regulate the expression of several genes with one miRNA able to target multiple genes and with one gene able to be simultaneously targeted by more than one miRNA. Therefore, it has become indispensable to… read more here.
Keywords: network based; network; analysis; target ... See more keywords
E2F1 somatic mutation within miRNA target site impairs gene regulation in colorectal cancer
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DOI: 10.1371/journal.pone.0181153
Abstract: Background Genetic studies have largely concentrated on the impact of somatic mutations found in coding regions, and have neglected mutations outside of these. However, 3’ untranslated regions (3' UTR) mutations can also disrupt or create… read more here.
Keywords: somatic mutation; mirna target; target; target site ... See more keywords
Prediction of miRNA targets by learning from interaction sequences
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0232578
Abstract: MicroRNAs (miRNAs) are involved in a diverse variety of biological processes through regulating the expression of target genes in the post-transcriptional level. So, it is of great importance to discover the targets of miRNAs in… read more here.
Keywords: mirna targets; target; prediction mirna; mirna target ... See more keywords