Quantification of purified endogenous miRNAs with high sensitivity and specificity
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19865-9
Abstract: MicroRNAs (miRNAs) are short (19–24 nt) non-coding RNAs that suppress the expression of protein coding genes at the post-transcriptional level. Differential expression profiles of miRNAs across a range of diseases have emerged as powerful biomarkers,… read more here.
Keywords: technique; mirnas high; high sensitivity; endogenous mirnas ... See more keywords
CRISPRi for specific inhibition of miRNA clusters and miRNAs with high sequence homology
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-10336-3
Abstract: miRNAs form a class of noncoding RNAs, involved in post-transcriptional regulation of gene expression, broadly studied for their involvement in physiological and pathological context. Inhibition of mature miRNA transcripts, commonly used in miRNA loss-of-function experiments,… read more here.
Keywords: mirna clusters; high sequence; inhibition; mirnas high ... See more keywords