Artificial miRNAs as therapeutic tools: Challenges and opportunities
Sign Up to like & getrecommendations! Published in 2021 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1640
Abstract: RNA interference (RNAi) technology has been used for almost two decades to study gene functions and in therapeutic approaches. It uses cellular machinery and small, designed RNAs in the form of synthetic small interfering RNAs… read more here.
Keywords: challenges opportunities; artificial mirnas; pri mirna; therapeutic tools ... See more keywords
Polyphenols target miRNAs as a therapeutic strategy for diabetic complications.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in food science and nutrition"
DOI: 10.1080/10408398.2022.2119364
Abstract: MiRNAs are a large group of non-coding RNAs which participate in different cellular pathways like inflammation and oxidation through transcriptional, post-transcriptional, and epigenetic regulation. In the post-transcriptional regulation, miRNA interacts with the 3'-UTR of mRNAs… read more here.
Keywords: target mirnas; polyphenols target; strategy diabetic; diabetic complications ... See more keywords
The Role of miRNAs as Therapeutic Tools in Sickle Cell Disease
Sign Up to like & getrecommendations! Published in 2021 at "Medicina"
DOI: 10.3390/medicina57101106
Abstract: Background and Objectives: Sickle cell disorder (SCD) is a paradigmatic example of a complex monogenic disorder. SCD is characterized by the production of abnormal hemoglobin, primarily in the deoxygenated state, which makes erythrocytes susceptible to… read more here.
Keywords: sickle cell; role mirnas; tools sickle; therapeutic tools ... See more keywords
miRNAs as Therapeutic Tools and Biomarkers for Prostate Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13030380
Abstract: Prostate cancer (PCa) is the fifth cause of tumor-related deaths in man worldwide. Despite the considerable improvement in the clinical management of PCa, several limitations emerged both in the screening for early diagnosis and in… read more here.
Keywords: prostate cancer; therapeutic tools; cancer; biomarkers prostate ... See more keywords