Miro1 provides neuroprotection via the mitochondrial trafficking pathway in a rat model of traumatic brain injury
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research"
DOI: 10.1016/j.brainres.2021.147685
Abstract: The outer mitochondrial membrane protein mitochondrial Rho-GTPase 1 (Miro1) is known to be involved in the regulation of mitochondrial transport required for neuronal protection. Previous reports established that disruption of Miro1-dependent mitochondrial movement could result… read more here.
Keywords: traumatic brain; rat model; brain injury; brain ... See more keywords
Generation of R272Q, S156A and K572R RHOT1/Miro1 point mutations in iPSCs from a healthy individual using FACS-assisted CRISPR/Cas9 genome editing.
Sign Up to like & getrecommendations! Published in 2021 at "Stem cell research"
DOI: 10.1016/j.scr.2021.102469
Abstract: The GTPase Miro1 is tail anchored into the mitochondrial outer membrane and tethers mitochondria to molecular motors which is crucial for mitochondrial transport. Miro1 contains two EF hand, ion binding domains important for calcium sequestration.… read more here.
Keywords: k572r; point mutations; r272q s156a; generation r272q ... See more keywords
Parkinson’s disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss
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DOI: 10.1093/brain/awaf051
Abstract: Abstract The complex and heterogeneous nature of Parkinson's disease (PD) is still not fully understood. However, increasing evidence supports mitochondrial impairment as a major driver of neurodegeneration. Miro1, a mitochondrial GTPase encoded by the RHOT1… read more here.
Keywords: mutant miro1; dopaminergic; parkinson disease; miro1 ... See more keywords
Miro1 expression alters global gene expression, ERK1/2 phosphorylation, oxidation, and cell cycle progression.
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DOI: 10.1242/jcs.263554
Abstract: Mitochondrial positioning supports localized energy and signaling requirements. Miro1 is necessary for attachment of mitochondria to microtubule motor proteins for trafficking. When Miro1 is deleted (Miro1-/-) from mouse embryonic fibroblasts (MEFs), mitochondria become sequestered to… read more here.
Keywords: miro1 mefs; miro1; erk1 phosphorylation; cell ... See more keywords
42-OR: Miro1 Negatively Regulates Skeletal Muscle Insulin Action in Mice with Diet-Induced Obesity and Hyperglycemia
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DOI: 10.2337/db25-42-or
Abstract: Introduction and Objective: Mitochondrial Rho-GTPase (MIRO1) is a critical regulator of mitochondrial trafficking and calcium homeostasis and by extension, mediates cellular energy balance and intracellular signaling. This study aimed to mechanistically decipher the role of… read more here.
Keywords: skeletal muscle; muscle insulin; insulin; none ... See more keywords
Miro1 Impairment in a Parkinson’s At-Risk Cohort
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2021.734273
Abstract: There is a lack of reliable molecular markers for Parkinson’s disease (PD) patients and at-risk individuals. The detection of the pre-symptomatic population of PD will empower more effective clinical intervention to delay or prevent disease… read more here.
Keywords: risk; risk individuals; miro1 impairment; cohort ... See more keywords