The Novel Gabapentinoid Mirogabalin Prevents Upregulation of α 2 δ-1 Subunit of Voltage-Gated Calcium Channels in Spinal Dorsal Horn in a Rat Model of Spinal Nerve Ligation
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DOI: 10.1055/a-1941-8907
Abstract: Abstract Gabapentinoids are specific ligands for the α 2 δ-1 subunit of voltage-gated calcium channels. This class of drugs, including gabapentin and pregabalin, exert various pharmacological effects and are widely used for the treatment of… read more here.
Keywords: mirogabalin; spinal dorsal; nerve; model ... See more keywords
Pharmacokinetics and metabolism of mirogabalin, a novel α2δ ligand, in rats and monkeys
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DOI: 10.1080/00498254.2022.2049396
Abstract: Abstract The purpose of this study was to investigate the pharmacokinetic behaviour of mirogabalin in rats and monkeys. Pharmacokinetic parameters of mirogabalin after its oral and intravenous administration were determined. Distribution study, mass balance study,… read more here.
Keywords: rats monkeys; mirogabalin; metabolism mirogabalin; oral administration ... See more keywords
Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K
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DOI: 10.1080/00498254.2022.2129517
Abstract: Abstract Mirogabalin is a α2δ ligand as well as pregabalin. The aim of this study was to clarify whether mirogabalin is a substrate of human LAT1, which involved in absorption and disposition of pregabalin, and… read more here.
Keywords: oat3 oct2; oct2; mirogabalin; pept1 pept2 ... See more keywords
The Clinical Application and Progress of Mirogabalin on Neuropathic Pain as a Novel Selective Gabapentinoids
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DOI: 10.1155/2023/4893436
Abstract: Background Neuropathic pain is a complex sort of pain that is detrimental to individuals' health, both physically and mentally, but merely a small portion of them could witness pain alleviation. Mirogabalin, by distinctive binding characteristics… read more here.
Keywords: clinical application; mirogabalin; neuropathic pain; pain ... See more keywords
Somnolence and Dizziness During Mirogabalin Treatment in Patients With Neuropathic Pain Related to Lumbar Disease Who Switched From Pregabalin: A Retrospective Study.
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DOI: 10.1177/21925682211031185
Abstract: STUDY DESIGN Multicenter retrospective study. OBJECTIVES To investigate adverse events (AEs) in patients with neuropathic pain related to lumbar disease who switched to mirogabalin from pregabalin. METHODS This study surveyed the records of 82 patients… read more here.
Keywords: somnolence dizziness; pregabalin; mirogabalin; group ... See more keywords
Mirogabalin for Central Neuropathic Pain After Spinal Cord Injury
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DOI: 10.1212/wnl.0000000000201709
Abstract: Background and Objectives Patients with spinal cord injury (SCI) commonly experience central neuropathic pain (CNeP), which is challenging to treat. Mirogabalin is effective for peripheral neuropathic pain, but evidence for CNeP is lacking. Methods This… read more here.
Keywords: mirogabalin; placebo; neuropathic pain; pain ... See more keywords