Mirror image of familial exudative vitreoretinopathy in identical twins
Sign Up to like & getrecommendations! Published in 2018 at "International Ophthalmology"
DOI: 10.1007/s10792-018-0875-5
Abstract: PurposeTo report the identical twins who had mirror fundus and angiographic images of familial exudative vitreoretinopathy (FEVR).Case presentationA pair of 16 year old female twins presented with mirror-image asymmetry of monocular decreased vision. The twins… read more here.
Keywords: exudative vitreoretinopathy; mirror image; familial exudative; identical twins ... See more keywords
Delusional Misidentification of the Mirror Image
Sign Up to like & getrecommendations! Published in 2019 at "Current Neurology and Neuroscience Reports"
DOI: 10.1007/s11910-019-0972-5
Abstract: Purpose of ReviewDelusional misidentification syndromes (DMS) include conditions in which a false belief about the identity of a person, place, or object occurs in the context of psychiatric or neurological disorders. One form of DMS… read more here.
Keywords: misidentification mirror; delusional misidentification; mirror; mirror image ... See more keywords
Using mirror-image peptides to enhance robustness and reproducibility in studying the amyloid β-protein.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.05.010
Abstract: Alzheimer's disease, the most common form of dementia, is a devastating disease that affects over 44 million people worldwide. One etiological agent of Alzheimer's, the amyloid β-protein (Aβ), is an aggregation-prone, intrinsically disordered peptide that… read more here.
Keywords: mirror image; using mirror; image peptides; amyloid protein ... See more keywords
An Auxiliary Approach for the Stereoselective Synthesis of Topologically Chiral Catenanes
Sign Up to like & getrecommendations! Published in 2019 at "Chem"
DOI: 10.1016/j.chempr.2019.03.008
Abstract: Summary Catenanes, molecules in which two rings are threaded through one another like links in a chain, can form as two structures related like an object and its mirror image but otherwise identical if the… read more here.
Keywords: synthesis topologically; topologically chiral; chiral catenanes; stereoselective synthesis ... See more keywords
Evaluating maintenance electroconvulsive therapy in Bipolar Disorders: 3-year mirror-image study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2021.10.052
Abstract: BACKGORUND Maintenance electroconvulsive therapy (mECT) is underused in the treatment of bipolar disorder (BD). We aimed to study the real-life effectiveness of mECT in BD. METHODS Naturalistic 3-year mirror-image study in individuals diagnosed with BD who… read more here.
Keywords: year; mirror image; study; number psychiatric ... See more keywords
The impact of fluphenazine withdrawal: a mirror-image study
Sign Up to like & getrecommendations! Published in 2024 at "Irish Journal of Psychological Medicine"
DOI: 10.1017/ipm.2024.2
Abstract: Abstract Background: Fluphenazine decanoate licenced as a long-acting injectable (LAI) first-generation antipsychotic (FGA) was withdrawn from sale in 2018. This study evaluates if its withdrawal resulted in increased relapse rates of psychosis in an Irish… read more here.
Keywords: fluphenazine; relapse; mirror image; withdrawal ... See more keywords
Design and Evaluation of Stable Cysteine-Modified Monobody Scaffolds for Mirror-Image Synthesis.
Sign Up to like & getrecommendations! Published in 2025 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.5c00181
Abstract: Mirror-image proteins (d-proteins) are promising therapeutic molecules with high biological stability and low immunogenicity. We recently developed a novel d-monobody scaffold variant with reduced immunogenicity. This variant incorporates two cysteine substitutions that enable the chemical… read more here.
Keywords: mirror image; monobody scaffold; monobody; synthesis ... See more keywords
De Novo Screening and Mirror Image Isomerization of Linear Peptides Targeting α7 Nicotinic Acetylcholine Receptor.
Sign Up to like & getrecommendations! Published in 2024 at "ACS chemical biology"
DOI: 10.1021/acschembio.3c00674
Abstract: As ligand-gated ion channels, nicotinic acetylcholine receptors (nAChRs) are widely distributed in the central and peripheral nervous systems and are associated with the pathogenesis of various degenerative neurological diseases. Here, we report the results of… read more here.
Keywords: mirror image; image; screening mirror; novo screening ... See more keywords
Engineering a Low-Immunogenic Mirror-Image VHH against Vascular Endothelial Growth Factor.
Sign Up to like & getrecommendations! Published in 2024 at "ACS chemical biology"
DOI: 10.1021/acschembio.4c00197
Abstract: Immunogenicity is a major caveat of protein therapeutics. In particular, the long-term administration of protein therapeutic agents leads to the generation of antidrug antibodies (ADAs), which reduce drug efficacy while eliciting adverse events. One promising… read more here.
Keywords: vascular endothelial; mirror image; image; vegf ... See more keywords
Chemokine-Binding All-D-CLIPS Peptides Identified Using Mirror-Image Phage Display
Sign Up to like & getrecommendations! Published in 2025 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.5c00726
Abstract: Chemokines are secreted blood proteins that steer leukocyte migration in the inflammatory response. Neutralization of chemokines is believed to be a beneficial therapeutic strategy for the treatment of inflammation-associated diseases. Proteolytically stable chemokine-binding peptides could… read more here.
Keywords: mirror image; chemokine binding; image phage; chemokine ... See more keywords
Mirror-image ligand discovery enabled by single-shot fast-flow synthesis of D-proteins
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-45634-z
Abstract: Widespread adoption of mirror-image biological systems presents difficulties in accessing the requisite D-protein substrates. In particular, mirror-image phage display has the potential for high-throughput generation of biologically stable macrocyclic D-peptide binders with potentially unique recognition… read more here.
Keywords: mirror image; image; synthesis; peptide ... See more keywords