In silico high throughput mutagenesis and screening of signal peptides to mitigate N-terminal heterogeneity of recombinant monoclonal antibodies
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DOI: 10.1080/19420862.2022.2044977
Abstract: ABSTRACT N-terminal heterogeneity resulting from non-uniform signal peptide (SP) cleavage can potentially affect biologics property attributes and result in extended product development timelines. Few studies are available on engineering SPs systematically to address miscleavage issues.… read more here.
Keywords: terminal heterogeneity; signal peptides; high throughput; miscleavage ... See more keywords