Neuron‐Derived Misfolded α‐Synuclein in Blood: A Potential Biomarker for Parkinson's Disease?
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders"
DOI: 10.1002/mds.29331
Abstract: To date, the clinical diagnosis of Parkinson’s disease (PD) is based on the assessment of motor and nonmotor symptoms, risk factors, and the response to levodopa. However, many patients with PD suffer from a late… read more here.
Keywords: disease; neuron derived; synuclein; parkinson disease ... See more keywords
Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0624-1
Abstract: The prion-like seeding of misfolded α-synuclein (αSyn) involved in the pathogenesis of Lewy body diseases (LBD) remains poorly understood at the molecular level. Using the real-time quaking-induced conversion (RT-QUIC) seeding assay, we investigated whether brain… read more here.
Keywords: prion like; like seeding; misfolded synuclein; seeding misfolded ... See more keywords
Baseline concentration of misfolded α‐synuclein aggregates in cerebrospinal fluid predicts risk of cognitive decline in Parkinson's disease
Sign Up to like & getrecommendations! Published in 2019 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12524
Abstract: The prognostic significance of misfolded α‐synuclein (α‐Syn) aggregates in Parkinson's disease (PD) has not been well investigated. The aim of this study was to reveal the relationship between misfolded α‐Syn aggregate concentration in cerebrospinal fluid… read more here.
Keywords: misfolded synuclein; parkinson disease; concentration; cognitive decline ... See more keywords
α-Synuclein in gut endocrine cells and its implications for Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.92295
Abstract: Parkinson's disease (PD) is a progressive neurodegenerative disease with devastating clinical manifestations. In PD, neuronal death is associated with intracellular aggregates of the neuronal protein α-synuclein known as Lewy bodies. Although the cause of sporadic… read more here.
Keywords: synuclein; synuclein gut; misfolded synuclein; disease ... See more keywords
Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder
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DOI: 10.1212/wnl.0000000000207147
Abstract: Background and Objectives Real-time quaking-induced conversion (RT-QuIC) assay detects misfolded α-synuclein (AS) in the skin and CSF of patients with the synucleinopathies Parkinson disease and dementia with Lewy bodies. Isolated REM sleep behavior disorder (IRBD)… read more here.
Keywords: csf; skin csf; rem sleep; isolated rem ... See more keywords