Protein misfolding, aggregation and mechanism of amyloid cytotoxicity: An overview and therapeutic strategies to inhibit aggregation.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.05.109
Abstract: Protein and peptides are converted from their soluble forms into highly ordered fibrillar aggregates under various conditions inside the cell. Such transitions confer diverse neurodegenerative diseases including Alzheimer's disease, Huntington's disease Prion's disease, Parkinson's disease,… read more here.
Keywords: protein; protein misfolding; aggregation; mechanism amyloid ... See more keywords
Insights into protein misfolding and aggregation enabled by solid-state NMR spectroscopy.
Sign Up to like & getrecommendations! Published in 2017 at "Solid state nuclear magnetic resonance"
DOI: 10.1016/j.ssnmr.2017.10.001
Abstract: The aggregation of proteins and peptides into a variety of insoluble, and often non-native, aggregated states plays a central role in many devastating diseases. Analogous processes undermine the efficacy of polypeptide-based biological pharmaceuticals, but are… read more here.
Keywords: solid state; misfolding aggregation; spectroscopy; state nmr ... See more keywords
Molecular Mechanism of Tau Misfolding and Aggregation: Insights from Molecular Dynamics Simulation.
Sign Up to like & getrecommendations! Published in 2023 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666230409145247
Abstract: Tau dysfunction has a close association with many neurodegenerative diseases, which are collectively referred to as tauopathies. Neurofibrillary tangles (NFTs) formed by misfolding and aggregation of tau are the main pathological process of tauopathy. Therefore,… read more here.
Keywords: simulation; aggregation; mechanism tau; misfolding aggregation ... See more keywords
Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00311
Abstract: [This corrects the article DOI: 10.3389/fnmol.2019.00262.]. read more here.
Keywords: protein misfolding; like propagation; corrigendum prion; misfolding aggregation ... See more keywords
Protein Misfolding and Aggregation: The Relatedness between Parkinson’s Disease and Hepatic Endoplasmic Reticulum Storage Disorders
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222212467
Abstract: Dysfunction of cellular homeostasis can lead to misfolding of proteins thus acquiring conformations prone to polymerization into pathological aggregates. This process is associated with several disorders, including neurodegenerative diseases, such as Parkinson’s disease (PD), and… read more here.
Keywords: storage; aggregation; misfolding aggregation; endoplasmic reticulum ... See more keywords
Deciphering the Effect of Lysine Acetylation on the Misfolding and Aggregation of Human Tau Fragment 171IPAKTPPAPK180 Using Molecular Dynamic Simulation and the Markov State Model
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052399
Abstract: The formation of neurofibrillary tangles (NFT) with β-sheet-rich structure caused by abnormal aggregation of misfolded microtubule-associated protein Tau is a hallmark of tauopathies, including Alzheimer’s Disease. It has been reported that acetylation, especially K174 located… read more here.
Keywords: aggregation; state; acetylation; tau ... See more keywords