Karyopherin abnormalities in neurodegenerative proteinopathies
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DOI: 10.1093/brain/awab201
Abstract: Abstract Neurodegenerative proteinopathies are characterised by progressive cell loss that is preceded by the mislocalisation and aberrant accumulation of proteins prone to aggregation. Despite their different physiological functions, disease-related proteins like tau, alpha-synuclein, Tar DNA… read more here.
Keywords: karyopherin abnormalities; abnormalities neurodegenerative; accumulation; neurodegenerative proteinopathies ... See more keywords
Mislocalisation of TDP‐43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex
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DOI: 10.1111/jnc.15214
Abstract: Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease pathologically characterised by mislocalisation of the RNA‐binding protein TAR‐DNA‐binding protein 43 (TDP‐43) from the nucleus to the cytoplasm. Changes to neuronal excitability and synapse dysfunction in… read more here.
Keywords: tdp; motor cortex; mislocalisation; hyperexcitability ... See more keywords
CHK2 overexpression and mislocalisation within mitotic structures enhances chromosomal instability and hepatocellular carcinoma progression
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DOI: 10.1136/gutjnl-2016-313114
Abstract: Objective Chromosomal instability (CIN) is the most common form of genomic instability, which promotes hepatocellular carcinoma (HCC) progression by enhancing tumour heterogeneity, drug resistance and immunity escape. CIN per se is an important factor of… read more here.
Keywords: hcc; progression; chk2; chromosomal instability ... See more keywords