Modulating RNA secondary and tertiary structures by mismatch binding ligands.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2019.05.006
Abstract: Much recent attention has been focused on small organic molecules binding to non-canonical structures of nucleic acids, especially, RNA. The Human Genome Project and the ENCODE (encyclopedia of DNA elements) project revealed that more than… read more here.
Keywords: binding ligands; molecules binding; dna; base pairs ... See more keywords
Inhibitory Effects of Mismatch Binding Molecules on the Repair Reaction of Uracil-Containing DNA.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00344
Abstract: The stable R-loop formed during transcription induces enzyme-mediated deamination of cytosine, and the uracil in the DNA produced activates the base excision repair (BER) pathway. DNA cleavage involved in the BER pathway is thought to… read more here.
Keywords: mismatch binding; inhibitory effects; xgg; reaction ... See more keywords
Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06936e
Abstract: Circular RNA (circRNA) is a covalently closed single-stranded RNA produced from pre-mRNAs via back-splicing reaction, an alternative form of splicing. Here, we show naphthyridine carbamate dimer (NCD) upregulating the production of a circRNA from a… read more here.
Keywords: mismatch binding; splicing reaction; rna; circular rna ... See more keywords
Unexpected moves: a conformational change in MutSĪ± enables high-affinity DNA mismatch binding
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad015
Abstract: Abstract The DNA mismatch repair protein MutSĪ± recognizes wrongly incorporated DNA bases and initiates their correction during DNA replication. Dysfunctions in mismatch repair lead to a predisposition to cancer. Here, we study the homozygous mutation… read more here.
Keywords: mismatch binding; affinity dna; dna; high affinity ... See more keywords