Association Between Survival and Metastatic Site in Mismatch Repair–Deficient Metastatic Colorectal Cancer Treated With First-line Pembrolizumab
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.0400
Abstract: This cohort study assesses the clinicopathological features, outcomes, and adverse events of older patients with metastatic colorectal adenocarcinomas. read more here.
Keywords: site mismatch; association survival; mismatch repair; survival metastatic ... See more keywords
Mismatch Repair Deficiency Testing in Patients With Colorectal Cancer and Nonadherence to Testing Guidelines in Young Adults
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.3580
Abstract: Importance Mismatch repair (MMR) deficiency of DNA has been observed in up to 15% of sporadic colorectal cancers (CRCs) and is a characteristic feature of Lynch syndrome, which has a higher incidence in young adults… read more here.
Keywords: testing guidelines; deficiency testing; mmr deficiency; mismatch repair ... See more keywords
Effects of CDX2 on prognosis and chemotherapy responsiveness in mismatch repair‐deficient colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "BJS Open"
DOI: 10.1002/bjs5.91
Abstract: Caudal‐related homeobox transcription factor 2 (CDX2) is an intestine‐specific transcription factor implicated in tumour differentiation, proliferation, cell adhesion and migration. Negative CDX2 status (CDX2−) is associated with worse prognosis in colorectal cancer and may identify… read more here.
Keywords: prognosis; colorectal cancer; repair deficient; mismatch repair ... See more keywords
Combination of lysine‐specific demethylase 6A (KDM6A) and mismatch repair (MMR) status is a potential prognostic factor in colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3602
Abstract: To evaluate the relationship between the DNA mismatch repair (MMR) status and histone lysine‐specific demethylase 6A (KDM6A) on the prognosis of colorectal cancer (CRC). read more here.
Keywords: lysine specific; repair mmr; mmr status; cancer ... See more keywords
The efficiency of neoadjuvant chemotherapy in colon cancer with mismatch repair deficiency
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DOI: 10.1002/cam4.5076
Abstract: Colon cancers with mismatch repair deficiency (dMMR) have specific clinicopathologic characteristics compared with mismatch repair proficiency (pMMR); however, the effect of MMR status on the efficiency of neoadjuvant chemotherapy (NCT) remains unclear. In our study,… read more here.
Keywords: neoadjuvant chemotherapy; mismatch repair; colon cancer; cancer ... See more keywords
CD169 + sinus macrophages in regional lymph nodes do not predict mismatch‐repair status of patients with colorectal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5747
Abstract: Mismatch‐repair deficiency and microsatellite instability‐high (dMMR/MSI‐H) colorectal cancer (CRC) is treated with programmed death (PD)‐1 antibody regardless of PD‐ligand (L)1 expression in tumor cells. We previously found that abundant CD169+ macrophages in regional lymph node… read more here.
Keywords: mismatch repair; regional lymph; colorectal cancer; cd169 ... See more keywords
Therapy with pembrolizumab in treatment‐naïve patients with nonmetastatic, mismatch repair deficient colorectal cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Cancer"
DOI: 10.1002/ijc.34420
Abstract: Therapy with immune checkpoint inhibitors (ICI) is effective in patients with metastatic mismatch‐repair deficient (dMMR) colorectal cancer (CRC); however, data on treatment with neoadjuvant ICI in patients with locally advanced CRC are limited. From March… read more here.
Keywords: mismatch repair; therapy; colorectal cancer; treatment ... See more keywords
Expanded roles for the MutL family of DNA mismatch repair proteins
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DOI: 10.1002/yea.3512
Abstract: The MutL family of DNA mismatch repair proteins plays a critical role in excising and repairing misincorporation errors during DNA replication. In many eukaryotes, members of this family have evolved to modulate and resolve recombination… read more here.
Keywords: mutl family; mismatch repair; family; dna mismatch ... See more keywords
Functional mismatch repair and inactive p53 drive sensitization of colorectal cancer cells to irinotecan via the IAP antagonist BV6
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Toxicology"
DOI: 10.1007/s00204-019-02513-7
Abstract: A common strategy to overcome acquired chemotherapy resistance is the combination of a specific anticancer drug (e.g., topoisomerase I inhibitor irinotecan) together with a putative sensitizer. The purpose of this study was to analyze the… read more here.
Keywords: cells irinotecan; bv6; p53; mismatch repair ... See more keywords
Do non-pathogenic variants of DNA mismatch repair genes modify neurofibroma load in neurofibromatosis type 1?
Sign Up to like & getrecommendations! Published in 2022 at "Child's Nervous System"
DOI: 10.1007/s00381-021-05436-w
Abstract: Non-pathogenic mismatch repair (MMR) gene variants can be associated with decreased MMR capacity in several settings. Due to an increased mutation rate, reduced MMR capacity leads to accumulation of somatic sequence changes in tumour suppressor… read more here.
Keywords: neurofibromatosis type; non; non pathogenic; mismatch repair ... See more keywords
Prevalence and clinicopathologic/molecular characteristics of mismatch repair-deficient colorectal cancer in the under-50-year-old Japanese population
Sign Up to like & getrecommendations! Published in 2017 at "Surgery Today"
DOI: 10.1007/s00595-017-1486-x
Abstract: PurposeTo clarify the prevalence and clinicopathologic/molecular characteristics of mismatch repair (MMR)-deficient colorectal cancer in the young Japanese population.MethodsImmunohistochemical analyses for MMR proteins (MLH1, MSH2, MSH6, and PMS2) were performed in formalin-fixed paraffin-embedded sections prepared from… read more here.
Keywords: characteristics mismatch; deficient colorectal; prevalence clinicopathologic; molecular characteristics ... See more keywords