Global misregulation of genes largely uncoupled to DNA methylome epimutations characterizes a congenital overgrowth syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13012-z
Abstract: Assisted reproductive therapies (ART) have become increasingly common worldwide and numerous retrospective studies have indicated that ART-conceived children are more likely to develop the overgrowth syndrome Beckwith-Wiedemann (BWS). In bovine, the use of ART can… read more here.
Keywords: methylome epimutations; overgrowth syndrome; dna methylome; misregulation ... See more keywords
Adaptive gene misregulation.
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DOI: 10.1093/genetics/iyaa044
Abstract: Because gene expression is important for evolutionary adaptation, its misregulation is an important cause of maladaptation. A misregulated gene can be incorrectly silent ("off") when a transcription factor (TF) that is required for its activation… read more here.
Keywords: gene misregulation; misregulation; misregulation adaptive; adaptation ... See more keywords