Asthma and the Missing Heritability Problem: Necessity for Multiomics Approaches in Determining Accurate Risk Profiles
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.822324
Abstract: Asthma is ranked among the most common chronic conditions and has become a significant public health issue due to the recent and rapid increase in its prevalence. Investigations into the underlying genetic factors predict a… read more here.
Keywords: heritability; heritability problem; missing heritability; risk ... See more keywords
Uncovering Missing Heritability in Rare Diseases
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DOI: 10.3390/genes10040275
Abstract: The problem of ‘missing heritability’ affects both common and rare diseases hindering: discovery, diagnosis, and patient care. The ‘missing heritability’ concept has been mainly associated with common and complex diseases where promising modern technological advances,… read more here.
Keywords: missing heritability; rare diseases; uncovering missing; heritability rare ... See more keywords
Phenotype-Based Genetic Analysis Reveals Missing Heritability of KIF11-Related Retinopathy: Clinical and Genetic Findings
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DOI: 10.3390/genes14010212
Abstract: The purpose of this study was to detect the missing heritability of patients with KIF11-related retinopathy and to describe their clinical and genetic characteristics. We enrolled 10 individuals from 7 unrelated families harboring a pathogenic… read more here.
Keywords: kif11 related; missing heritability; clinical genetic; analysis ... See more keywords
Tackling Missing Heritability by Use of an Optimum Curve: A Systematic Review and Meta-Analysis
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DOI: 10.3390/ijms20205104
Abstract: Missing heritability is a common problem in psychiatry that impedes precision medicine approaches to autism and other heritable complex disorders. This proof-of-concept study uses a systematic review and meta-analysis of the association between variants of… read more here.
Keywords: missing heritability; review meta; systematic review; optimum curve ... See more keywords