Open-pFind Verified Four Missing Proteins from Multi-Tissues.
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DOI: 10.1021/acs.jproteome.0c00370
Abstract: The Chromosome-Centric Human Proteome Project (C-HPP) was launched in 2012 to perfect the annotation of human protein existence by identifying stronger evidence of the expression of missing proteins (MPs) at the protein level. After an… read more here.
Keywords: open pfind; protein; missing proteins; four missing ... See more keywords
Enhanced Validation of Antibodies Enables the Discovery of Missing Proteins
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DOI: 10.1021/acs.jproteome.0c00486
Abstract: The localization of proteins at a tissue- or cell-type-specific level is tightly linked to the protein function. To better understand each protein’s role in cellular systems, spatial information constitutes an important complement to quantitative data.… read more here.
Keywords: missing proteins; antibodies enables; enhanced validation; validation antibodies ... See more keywords
Naive Pluripotent and Trophoblastic Stem Cell Lines as a Model for Detecting Missing Proteins in the Context of the Chromosome-Centric Human Proteome Project.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00496
Abstract: The Chromosome-centric Human Proteome Project (C-HPP) aims at identifying the proteins as gene products encoded by the human genome, characterizing their isoforms and functions. The existence of products has now been confirmed for 93.2% of… read more here.
Keywords: missing proteins; chromosome centric; pluripotent; centric human ... See more keywords
Digging More Missing Proteins Using an Enrichment Approach with ProteoMiner.
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DOI: 10.1021/acs.jproteome.7b00353
Abstract: Human Proteome Project (HPP) aims at mapping entire human proteins with a systematic effort upon all the emerging techniques, which would enhance understanding of human biology and lay a foundation for development of medical applications.… read more here.
Keywords: digging missing; missing proteins; abundance proteins; unique peptides ... See more keywords
Identification of Missing Proteins in Normal Human Cerebrospinal Fluid.
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DOI: 10.1021/acs.jproteome.8b00194
Abstract: The cerebrospinal fluid (CSF) proteome data set presented herein was obtained after immunodepletion of abundant proteins and off-gel electrophoresis fractionation of a commercial pool of normal human CSF; liquid chromatography tandem mass spectrometry analysis was… read more here.
Keywords: missing proteins; normal human; identification; data set ... See more keywords
Integration of Transcriptomics and Antibody-Based Proteomics for Exploration of Proteins Expressed in Specialized Tissues.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.8b00406
Abstract: A large portion of human proteins are referred to as missing proteins, defined as protein-coding genes that lack experimental data on the protein level due to factors such as temporal expression, expression in tissues that… read more here.
Keywords: specialized tissues; missing proteins; exploration; transcriptomics antibody ... See more keywords
Progress and pitfalls in finding the ‘missing proteins’ from the human proteome map
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Proteomics"
DOI: 10.1080/14789450.2017.1265450
Abstract: ABSTRACT Introduction: The Human Proteome Project was launched with two main goals: the comprehensive and systematic definition of the human proteome map and the development of ready to use analytical tools to measure relevant proteins… read more here.
Keywords: proteome map; human proteome; progress; missing proteins ... See more keywords
Is It Possible to Find Needles in a Haystack? Meta-Analysis of 1000+ MS/MS Files Provided by the Russian Proteomic Consortium for Mining Missing Proteins
Sign Up to like & getrecommendations! Published in 2020 at "Proteomes"
DOI: 10.3390/proteomes8020012
Abstract: Despite direct or indirect efforts of the proteomic community, the fraction of blind spots on the protein map is still significant. Almost 11% of human genes encode missing proteins; the existence of which proteins is… read more here.
Keywords: russian proteomic; consortium; needles haystack; missing proteins ... See more keywords