Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13113-5
Abstract: Current doctrine is that microvascular inflammation (MVI) triggered by a transplant -recipient antibody response against alloantigens (antibody-mediated rejection) is the main cause of graft failure. Here, we show that histological lesions are not mediated by… read more here.
Keywords: chronic vascular; graft; rejection; vascular rejection ... See more keywords
Missing Self-Induced Microvascular Rejection of Kidney Allografts: A Population-Based Study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2020111558
Abstract: BACKGROUND Circulating anti-HLA donor-specific antibodies (HLA-DSA) are often absent in kidney transplant recipients with microvascular inflammation (MVI). Missing self, the inability of donor endothelial cells to provide HLA I-mediated signals to inhibitory killer cell Ig-like… read more here.
Keywords: mvi; missing self; kidney; hla dsa ... See more keywords